抗人 MMP9 抗体对
01AB04093
Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent endopeptidase that plays crucial roles in both physiological and pathological tissue remodeling. It degrades extracellular matrix proteins and activates cytokines and chemokines, regulating inflammation, fibrosis, and immune responses. MMP-9 is involved in various cardiovascular diseases, including hypertension, atherosclerosis, and myocardial infarction. In neurodegenerative disorders like Parkinson's disease, elevated MMP-9 levels are associated with cognitive impairment and may contribute to neuroinflammation and dopaminergic neuronal death. MMP-9 also plays a role in respiratory viral infections, with increased expression observed in influenza, SARS-CoV-2, and respiratory syncytial virus infections. While MMP-9 is essential for normal physiological processes, its dysregulation can exacerbate disease progression. As such, MMP-9 has emerged as a potential biomarker and therapeutic target for various pathologies.
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技术参数
- 靶点基因名
- MMP9
- 基因别名
- CLG4B
- 蛋白别名
- matrix metallopeptidase 9; MMP9
- UniProt
- P14780
- 物种
- Human
产品详情
- 靶点名称
- MMP9
- 蛋白名称
- matrix metallopeptidase 9
- 蛋白别名
- Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
- 靶点基因名
- MMP9
- 基因别名
- CLG4B
- UniProt
- P14780
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent endopeptidase that plays crucial roles in both physiological and pathological tissue remodeling. It degrades extracellular matrix proteins and activates cytokines and chemokines, regulating inflammation, fibrosis, and immune responses. MMP-9 is involved in various cardiovascular diseases, including hypertension, atherosclerosis, and myocardial infarction. In neurodegenerative disorders like Parkinson's disease, elevated MMP-9 levels are associated with cognitive impairment and may contribute to neuroinflammation and dopaminergic neuronal death. MMP-9 also plays a role in respiratory viral infections, with increased expression observed in influenza, SARS-CoV-2, and respiratory syncytial virus infections. While MMP-9 is essential for normal physiological processes, its dysregulation can exacerbate disease progression. As such, MMP-9 has emerged as a potential biomarker and therapeutic target for various pathologies.