人 MMP13 抗体对
01AB02678
MMP13 (matrix metalloproteinase-13), also known as collagenase-3, plays a critical role in the pathogenesis of osteoarthritis (OA) by degrading type II collagen in articular cartilage. MMP13 is the primary MMP involved in cartilage destruction and is an attractive target for OA treatment. Increased expression of MMP13 in chondrocytes tips the balance towards cartilage catabolism, leading to OA development and progression. MMP13 also mediates osteoclast fusion and activity, contributing to multiple myeloma-induced bone disease. Additionally, MMP13 promotes tumor angiogenesis both directly and indirectly. In summary, MMP13 is a key player in the pathogenesis of OA and other diseases, making it an attractive target for therapeutic interventions.
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技术参数
- 靶点基因名
- MMP13
- 蛋白别名
- matrix metallopeptidase 13; MMP13
- UniProt
- P45452
- 物种
- Human
产品详情
- 靶点名称
- MMP13
- 蛋白名称
- matrix metallopeptidase 13
- 蛋白别名
- Collagenase 3; Matrix metalloproteinase-13; MMP-13
- 靶点基因名
- MMP13
- UniProt
- P45452
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MMP13 (matrix metalloproteinase-13), also known as collagenase-3, plays a critical role in the pathogenesis of osteoarthritis (OA) by degrading type II collagen in articular cartilage. MMP13 is the primary MMP involved in cartilage destruction and is an attractive target for OA treatment. Increased expression of MMP13 in chondrocytes tips the balance towards cartilage catabolism, leading to OA development and progression. MMP13 also mediates osteoclast fusion and activity, contributing to multiple myeloma-induced bone disease. Additionally, MMP13 promotes tumor angiogenesis both directly and indirectly. In summary, MMP13 is a key player in the pathogenesis of OA and other diseases, making it an attractive target for therapeutic interventions.