抗人 MMP1 抗体对
01AB02731
Matrix Metalloproteinase 1 (MMP1), also known as interstitial collagenase, is an enzyme that plays a vital role in the degradation of extracellular matrix components, particularly collagen. This protein is crucial for normal physiological processes such as tissue remodeling, wound healing, and embryogenesis. MMP1 is expressed in various tissues, including the skin, lung, and synovium, and its activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs). Dysregulation of MMP1 has been implicated in several diseases, particularly in inflammatory conditions and cancer. Elevated levels of MMP1 are associated with rheumatoid arthritis, where it contributes to joint destruction, and with various cancers, including breast and prostate cancer, where it enhances tumor invasion and metastasis. The dual role of MMP1 in both normal tissue homeostasis and disease progression highlights its potential as a therapeutic target.
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技术参数
- 靶点基因名
- MMP1
- 基因别名
- CLG
- 蛋白别名
- matrix metallopeptidase 1; MMP1
- UniProt
- P03956
- 物种
- Human
产品详情
- 靶点名称
- MMP1
- 蛋白名称
- matrix metallopeptidase 1
- 蛋白别名
- Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
- 靶点基因名
- MMP1
- 基因别名
- CLG
- UniProt
- P03956
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Matrix Metalloproteinase 1 (MMP1), also known as interstitial collagenase, is an enzyme that plays a vital role in the degradation of extracellular matrix components, particularly collagen. This protein is crucial for normal physiological processes such as tissue remodeling, wound healing, and embryogenesis. MMP1 is expressed in various tissues, including the skin, lung, and synovium, and its activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs). Dysregulation of MMP1 has been implicated in several diseases, particularly in inflammatory conditions and cancer. Elevated levels of MMP1 are associated with rheumatoid arthritis, where it contributes to joint destruction, and with various cancers, including breast and prostate cancer, where it enhances tumor invasion and metastasis. The dual role of MMP1 in both normal tissue homeostasis and disease progression highlights its potential as a therapeutic target.