人 MMEL1 抗体对
01AB01235
Membrane metalloendopeptidase like 1 (MMEL1) is a type II transmembrane metalloprotease belonging to the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family, which plays key roles in pain perception, arterial pressure regulation, phosphate metabolism, and homeostasis. MMEL1 is primarily expressed in the testis, with weaker expression in the brain, kidney, and heart, and is thought to function both as a membrane-bound and secreted protein. It is involved in sperm function, potentially modulating fertilization and early embryonic development by degrading a broad range of small peptides, especially those shorter than 3 kDa with neutral bulky aliphatic or aromatic residues, sharing substrate specificity with MME. Disease associations for MMEL1 include primary biliary cholangitis and systolic heart failure, and it is implicated in pathways related to amyloid-beta metabolism and degradation, which may link it to neurodegenerative processes.
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技术参数
- 靶点基因名
- MMEL1
- 基因别名
- MELL1; MMEL2; NEP2
- 蛋白别名
- membrane metalloendopeptidase like 1; MMEL1
- UniProt
- Q495T6
- 物种
- Human
产品详情
- 靶点名称
- MMEL1
- 蛋白名称
- membrane metalloendopeptidase like 1
- 蛋白别名
- Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2; NEP2(m); Neprilysin II; NEPII; Neprilysin-2; NEP2; NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1; soluble form; Neprilysin-2 secreted; NEP2(s)]
- 靶点基因名
- MMEL1
- 基因别名
- MELL1; MMEL2; NEP2
- UniProt
- Q495T6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Membrane metalloendopeptidase like 1 (MMEL1) is a type II transmembrane metalloprotease belonging to the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family, which plays key roles in pain perception, arterial pressure regulation, phosphate metabolism, and homeostasis. MMEL1 is primarily expressed in the testis, with weaker expression in the brain, kidney, and heart, and is thought to function both as a membrane-bound and secreted protein. It is involved in sperm function, potentially modulating fertilization and early embryonic development by degrading a broad range of small peptides, especially those shorter than 3 kDa with neutral bulky aliphatic or aromatic residues, sharing substrate specificity with MME. Disease associations for MMEL1 include primary biliary cholangitis and systolic heart failure, and it is implicated in pathways related to amyloid-beta metabolism and degradation, which may link it to neurodegenerative processes.