人 MICB 抗体对
01AB01757
MHC class I polypeptide-related sequence B (MICB) is a membrane-bound, nonclassical MHC class I–related protein that functions as a stress-inducible ligand for the activating receptor NKG2D. Unlike classical MHC I molecules, MICB does not associate with β2-microglobulin or present peptide antigens. Instead, its expression is upregulated by cellular stress, such as heat shock or DNA damage, to trigger cytotoxicity and cytokine secretion in NK cells and CD8+ T cells. MICB plays a significant role in tumor immunosurveillance; however, its proteolytic shedding into a soluble form can down-modulate NKG2D expression, allowing tumor cells to evade immune detection. Polymorphisms and expression levels of MICB are also linked to susceptibility to various infectious diseases and immune-mediated conditions.
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技术参数
- 靶点基因名
- MICB
- 基因别名
- PERB11.2
- 蛋白别名
- MHC class I polypeptide-related sequence B; MICB
- UniProt
- Q29980
- 物种
- Human
产品详情
- 靶点名称
- MICB
- 蛋白名称
- MHC class I polypeptide-related sequence B
- 蛋白别名
- MHC class I polypeptide-related sequence B; MIC-B
- 靶点基因名
- MICB
- 基因别名
- PERB11.2
- UniProt
- Q29980
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MHC class I polypeptide-related sequence B (MICB) is a membrane-bound, nonclassical MHC class I–related protein that functions as a stress-inducible ligand for the activating receptor NKG2D. Unlike classical MHC I molecules, MICB does not associate with β2-microglobulin or present peptide antigens. Instead, its expression is upregulated by cellular stress, such as heat shock or DNA damage, to trigger cytotoxicity and cytokine secretion in NK cells and CD8+ T cells. MICB plays a significant role in tumor immunosurveillance; however, its proteolytic shedding into a soluble form can down-modulate NKG2D expression, allowing tumor cells to evade immune detection. Polymorphisms and expression levels of MICB are also linked to susceptibility to various infectious diseases and immune-mediated conditions.