抗人 MICALL1 抗体对
01AB01991
MICAL like 1 (MICALL1) is a cytoplasmic, membrane-associated protein that localizes to tubular recycling endosomes, where it serves as a critical scaffold in endocytic recycling pathways. It functions as a downstream effector for Rab GTPases, including Rab8, Rab10, and Rab13, to recruit cytosolic factors necessary for endosomal membrane tubulation and the recycling of cargo to the plasma membrane. MICALL1 contains modular domains, such as coiled-coil regions, that facilitate interactions with phosphatidic acid and various small GTPases. Broadly expressed in epithelial and neuronal tissues, the protein is essential for maintaining polarized trafficking and efficient intracellular transport mechanisms.
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技术参数
- 靶点基因名
- MICALL1
- 基因别名
- KIAA1668; MIRAB13
- 蛋白别名
- MICAL like 1; MICALL1
- UniProt
- Q8N3F8
- 物种
- Human
产品详情
- 靶点名称
- MICALL1
- 蛋白名称
- MICAL like 1
- 蛋白别名
- MICAL-like protein 1; Molecule interacting with Rab13; MIRab13
- 靶点基因名
- MICALL1
- 基因别名
- KIAA1668; MIRAB13
- UniProt
- Q8N3F8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MICAL like 1 (MICALL1) is a cytoplasmic, membrane-associated protein that localizes to tubular recycling endosomes, where it serves as a critical scaffold in endocytic recycling pathways. It functions as a downstream effector for Rab GTPases, including Rab8, Rab10, and Rab13, to recruit cytosolic factors necessary for endosomal membrane tubulation and the recycling of cargo to the plasma membrane. MICALL1 contains modular domains, such as coiled-coil regions, that facilitate interactions with phosphatidic acid and various small GTPases. Broadly expressed in epithelial and neuronal tissues, the protein is essential for maintaining polarized trafficking and efficient intracellular transport mechanisms.