人 METTL2A 抗体对
01AB00310
Methyltransferase 2A, tRNA N3-cytidine (METTL2A) is a key enzyme involved in the methylation of tRNA, specifically catalyzing the N3-methylcytidine modification at position 32 of the tRNA anticodon loop, which is crucial for proper tRNA function and protein synthesis. Located on chromosome 17, METTL2A has been implicated in various cancers, with studies showing its overexpression in several tumor types including breast and lung cancers, suggesting a potential role as an oncogene. The enzyme's specificity and recognition of tRNA substrates are influenced by sequence motifs within the anticodon loop and modified nucleotides at position 37.
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技术参数
- 靶点基因名
- METTL2A
- 基因别名
- METTL2
- 蛋白别名
- methyltransferase 2A, tRNA N3-cytidine; METTL2A
- UniProt
- Q96IZ6
- 物种
- Human
产品详情
- 靶点名称
- METTL2A
- 蛋白名称
- methyltransferase 2A, tRNA N3-cytidine
- 蛋白别名
- tRNA N(3)-methylcytidine methyltransferase METTL2A; Methyltransferase-like protein 2A
- 靶点基因名
- METTL2A
- 基因别名
- METTL2
- UniProt
- Q96IZ6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Methyltransferase 2A, tRNA N3-cytidine (METTL2A) is a key enzyme involved in the methylation of tRNA, specifically catalyzing the N3-methylcytidine modification at position 32 of the tRNA anticodon loop, which is crucial for proper tRNA function and protein synthesis. Located on chromosome 17, METTL2A has been implicated in various cancers, with studies showing its overexpression in several tumor types including breast and lung cancers, suggesting a potential role as an oncogene. The enzyme's specificity and recognition of tRNA substrates are influenced by sequence motifs within the anticodon loop and modified nucleotides at position 37.