人蛋氨酸氨肽酶 2 抗体对
01AB00307
Methionyl aminopeptidase 2 (METAP2) is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins, playing a critical role in protein maturation and stability. METAP2 is particularly important in endothelial cell growth and proliferation during tumor angiogenesis and tumor cell proliferation, making it a promising target in oncology. The enzyme is also involved in protecting the alpha subunit of eukaryotic initiation factor 2 (eIF2) from inhibitory phosphorylation, thereby regulating protein synthesis. Increased expression of METAP2 is associated with various forms of cancer, and inhibitors such as fumagillin and ovalicin have shown anti-cancer effects by irreversibly binding to the active site of METAP2.
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技术参数
- 靶点基因名
- METAP2
- 基因别名
- MNPEP; P67EIF2
- 蛋白别名
- methionyl aminopeptidase 2; Methionine Aminopeptidase 2
- UniProt
- P50579
- 物种
- Human
产品详情
- 靶点名称
- Methionine Aminopeptidase 2
- 蛋白名称
- methionyl aminopeptidase 2
- 蛋白别名
- Methionine aminopeptidase 2; MAP 2; MetAP 2; Initiation factor 2-associated 67 kDa glycoprotein; p67; p67eIF2; Peptidase M
- 靶点基因名
- METAP2
- 基因别名
- MNPEP; P67EIF2
- UniProt
- P50579
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Methionyl aminopeptidase 2 (METAP2) is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins, playing a critical role in protein maturation and stability. METAP2 is particularly important in endothelial cell growth and proliferation during tumor angiogenesis and tumor cell proliferation, making it a promising target in oncology. The enzyme is also involved in protecting the alpha subunit of eukaryotic initiation factor 2 (eIF2) from inhibitory phosphorylation, thereby regulating protein synthesis. Increased expression of METAP2 is associated with various forms of cancer, and inhibitors such as fumagillin and ovalicin have shown anti-cancer effects by irreversibly binding to the active site of METAP2.