人金属蛋白酶抑制剂1抗体对
01AB00428
TIMP metallopeptidase inhibitor 1 (TIMP1) is a 28 kDa secreted glycoprotein encoded by the TIMP1 gene, belonging to the TIMP family of proteins that regulate extracellular matrix (ECM) turnover by inhibiting matrix metalloproteinases (MMPs), particularly MMP-1, -2, -3, -7, -9, and -13. TIMP1 binds reversibly to MMPs via its N-terminal domain, blocking their proteolytic activity, and also exhibits growth-promoting and anti-apoptotic properties through interactions with cell-surface receptors like CD63 and integrins. Elevated TIMP1 levels are implicated in pathological conditions, including cancer and fibrosis. In cancers (e.g., breast, colorectal), TIMP1 overexpression correlates with tumor progression, metastasis, and poor prognosis due to its dual role in ECM stabilization and promotion of cell survival. In fibrosis (e.g., liver cirrhosis, pulmonary fibrosis), excessive TIMP1 disrupts ECM homeostasis, leading to tissue scarring by reducing MMP-mediated degradation of collagen.
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技术参数
- 靶点基因名
- TIMP1
- 基因别名
- CLGI; TIMP
- 蛋白别名
- TIMP metallopeptidase inhibitor 1; Metalloproteinase Inhibitor 1
- UniProt
- P01033
- 物种
- Human
产品详情
- 靶点名称
- Metalloproteinase Inhibitor 1
- 蛋白名称
- TIMP metallopeptidase inhibitor 1
- 蛋白别名
- Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
- 靶点基因名
- TIMP1
- 基因别名
- CLGI; TIMP
- UniProt
- P01033
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TIMP metallopeptidase inhibitor 1 (TIMP1) is a 28 kDa secreted glycoprotein encoded by the TIMP1 gene, belonging to the TIMP family of proteins that regulate extracellular matrix (ECM) turnover by inhibiting matrix metalloproteinases (MMPs), particularly MMP-1, -2, -3, -7, -9, and -13. TIMP1 binds reversibly to MMPs via its N-terminal domain, blocking their proteolytic activity, and also exhibits growth-promoting and anti-apoptotic properties through interactions with cell-surface receptors like CD63 and integrins. Elevated TIMP1 levels are implicated in pathological conditions, including cancer and fibrosis. In cancers (e.g., breast, colorectal), TIMP1 overexpression correlates with tumor progression, metastasis, and poor prognosis due to its dual role in ECM stabilization and promotion of cell survival. In fibrosis (e.g., liver cirrhosis, pulmonary fibrosis), excessive TIMP1 disrupts ECM homeostasis, leading to tissue scarring by reducing MMP-mediated degradation of collagen.