人 MEIS2 抗体对
01AB03065
Meis homeobox 2 (MEIS2) is a TALE-class homeodomain transcription factor that functions as a critical DNA-binding cofactor for HOX and PBX proteins. It stabilizes transcriptional complexes to regulate gene expression essential for the development of the brain, heart, limbs, and pancreas. Isoform-specific activities include modulating pancreatic acinar transcription and myeloid differentiation. Pathogenic loss-of-function variants in MEIS2 cause an autosomal dominant syndrome characterized by cleft palate, congenital cardiac defects, and intellectual disability. In oncology, MEIS2 supports cell survival and proliferation in neuroblastoma and acute myeloid leukemia, where its inhibition induces apoptosis, marking it as a potential therapeutic target.
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技术参数
- 靶点基因名
- MEIS2
- 基因别名
- MRG1
- 蛋白别名
- Meis homeobox 2; MEIS2
- UniProt
- O14770
- 物种
- Human
产品详情
- 靶点名称
- MEIS2
- 蛋白名称
- Meis homeobox 2
- 蛋白别名
- Homeobox protein Meis2; Meis1-related protein 1
- 靶点基因名
- MEIS2
- 基因别名
- MRG1
- UniProt
- O14770
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Meis homeobox 2 (MEIS2) is a TALE-class homeodomain transcription factor that functions as a critical DNA-binding cofactor for HOX and PBX proteins. It stabilizes transcriptional complexes to regulate gene expression essential for the development of the brain, heart, limbs, and pancreas. Isoform-specific activities include modulating pancreatic acinar transcription and myeloid differentiation. Pathogenic loss-of-function variants in MEIS2 cause an autosomal dominant syndrome characterized by cleft palate, congenital cardiac defects, and intellectual disability. In oncology, MEIS2 supports cell survival and proliferation in neuroblastoma and acute myeloid leukemia, where its inhibition induces apoptosis, marking it as a potential therapeutic target.