人 MEGF11 抗体对
01AB02857
Multiple EGF like domains 11 (MEGF11) is a transmembrane protein that plays a specialized role in homotypic cell-cell adhesion and repulsion mechanisms. In the retina, it is essential for regulating the mosaic spacing of specific neuronal subtypes, ensuring an even distribution of cells across the visual field for optimal sensory processing. Beyond the visual system, MEGF11 is critical for cerebellar development, where it organizes the network formation of Purkinje cells by controlling synaptic transmission from parallel fibers. Its function is vital for maintaining motor coordination and proper cerebellar architecture. Clinically, MEGF11 is associated with Congenital Myopathy 10A, a severe muscle disorder characterized by significant weakness and structural anomalies. Research in animal models has shown that the loss of MEGF11 leads to ectopic neuronal positioning and impaired neurotransmitter release, underscoring its importance in both neuromuscular integrity and the precise spatial organization of the central nervous system.
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技术参数
- 靶点基因名
- MEGF11
- 基因别名
- KIAA1781
- 蛋白别名
- multiple EGF like domains 11; MEGF11
- UniProt
- A6BM72
- 物种
- Human
产品详情
- 靶点名称
- MEGF11
- 蛋白名称
- multiple EGF like domains 11
- 蛋白别名
- Multiple epidermal growth factor-like domains protein 11; Multiple EGF-like domains protein 11
- 靶点基因名
- MEGF11
- 基因别名
- KIAA1781
- UniProt
- A6BM72
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Multiple EGF like domains 11 (MEGF11) is a transmembrane protein that plays a specialized role in homotypic cell-cell adhesion and repulsion mechanisms. In the retina, it is essential for regulating the mosaic spacing of specific neuronal subtypes, ensuring an even distribution of cells across the visual field for optimal sensory processing. Beyond the visual system, MEGF11 is critical for cerebellar development, where it organizes the network formation of Purkinje cells by controlling synaptic transmission from parallel fibers. Its function is vital for maintaining motor coordination and proper cerebellar architecture. Clinically, MEGF11 is associated with Congenital Myopathy 10A, a severe muscle disorder characterized by significant weakness and structural anomalies. Research in animal models has shown that the loss of MEGF11 leads to ectopic neuronal positioning and impaired neurotransmitter release, underscoring its importance in both neuromuscular integrity and the precise spatial organization of the central nervous system.