抗人 MCEMP1 抗体对
01AB01527
Mast cell expressed membrane protein 1 (MCEMP1) is a single-pass type II transmembrane protein predominantly expressed in myeloid lineage cells, including lung-resident mast cells, classical monocytes, and alveolar macrophages. It functions as an adaptor for the receptor tyrosine kinase KIT, facilitating stem cell factor (SCF)-mediated mast cell proliferation through its immunoreceptor tyrosine-based activation motif, enhancing KIT autophosphorylation and downstream signaling. MCEMP1 is upregulated by transforming growth factor beta (TGFβ) via SMAD3 and SP1 transcription factors, influencing monocyte chemotaxis, adhesion, and migration by modulating RHO GTPase activity. Its expression is markedly increased in inflammatory lung conditions such as asthma and idiopathic pulmonary fibrosis (IPF), correlating with disease severity. In asthma models, MCEMP1 deficiency reduces airway inflammation and lung impairment, while in IPF, elevated MCEMP1 in monocytes and alveolar macrophages associates with poor prognosis and promotes fibrotic progression by regulating immune cell migration and activation.
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技术参数
- 靶点基因名
- MCEMP1
- 基因别名
- C19orf59
- 蛋白别名
- mast cell expressed membrane protein 1; MCEMP1
- UniProt
- Q8IX19
- 物种
- Human
产品详情
- 靶点名称
- MCEMP1
- 蛋白名称
- mast cell expressed membrane protein 1
- 蛋白别名
- Mast cell-expressed membrane protein 1
- 靶点基因名
- MCEMP1
- 基因别名
- C19orf59
- UniProt
- Q8IX19
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Mast cell expressed membrane protein 1 (MCEMP1) is a single-pass type II transmembrane protein predominantly expressed in myeloid lineage cells, including lung-resident mast cells, classical monocytes, and alveolar macrophages. It functions as an adaptor for the receptor tyrosine kinase KIT, facilitating stem cell factor (SCF)-mediated mast cell proliferation through its immunoreceptor tyrosine-based activation motif, enhancing KIT autophosphorylation and downstream signaling. MCEMP1 is upregulated by transforming growth factor beta (TGFβ) via SMAD3 and SP1 transcription factors, influencing monocyte chemotaxis, adhesion, and migration by modulating RHO GTPase activity. Its expression is markedly increased in inflammatory lung conditions such as asthma and idiopathic pulmonary fibrosis (IPF), correlating with disease severity. In asthma models, MCEMP1 deficiency reduces airway inflammation and lung impairment, while in IPF, elevated MCEMP1 in monocytes and alveolar macrophages associates with poor prognosis and promotes fibrotic progression by regulating immune cell migration and activation.