抗人 MBP 抗体对
01AB03784
Myelin Basic Protein (MBP) is a key structural component of the myelin sheath that insulates axons in the central nervous system. It plays a crucial role in the formation and maintenance of compact myelin, facilitating efficient nerve signal conduction. MBP exists in multiple isoforms arising from alternative splicing, with the 18.5 kDa isoform being the most abundant in adult human myelin. Disruption or degradation of MBP is associated with demyelination and neurodegeneration in diseases like multiple sclerosis (MS). Genetic variants in the MBP gene can influence the clinical course of MS, with certain variants predicting higher relapse rates and disability progression, potentially through mechanisms involving microRNA regulation. Additionally, MBP fragments released during myelin breakdown can trigger further myelin disassembly and serve as autoantigens driving the autoimmune response in MS.
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技术参数
- 靶点基因名
- MBP
- 蛋白别名
- myelin basic protein; MBP
- UniProt
- P02686
- 物种
- Human
产品详情
- 靶点名称
- MBP
- 蛋白名称
- myelin basic protein
- 蛋白别名
- Myelin basic protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein
- 靶点基因名
- MBP
- UniProt
- P02686
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Myelin Basic Protein (MBP) is a key structural component of the myelin sheath that insulates axons in the central nervous system. It plays a crucial role in the formation and maintenance of compact myelin, facilitating efficient nerve signal conduction. MBP exists in multiple isoforms arising from alternative splicing, with the 18.5 kDa isoform being the most abundant in adult human myelin. Disruption or degradation of MBP is associated with demyelination and neurodegeneration in diseases like multiple sclerosis (MS). Genetic variants in the MBP gene can influence the clinical course of MS, with certain variants predicting higher relapse rates and disability progression, potentially through mechanisms involving microRNA regulation. Additionally, MBP fragments released during myelin breakdown can trigger further myelin disassembly and serve as autoantigens driving the autoimmune response in MS.