人 MAST4 抗体对
01AB04090
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) is a serine/threonine kinase that plays a significant role in various cellular processes, particularly in the regulation of cell signaling pathways involved in differentiation and development. MAST4 is primarily associated with microtubules and is implicated in the modulation of cytoskeletal dynamics, influencing cell shape and motility. Research has shown that MAST4 is essential for the differentiation of mesenchymal stem cells (MSCs) into chondrocytes and osteoblasts by mediating signaling pathways such as TGF-β and Wnt. Dysregulation of MAST4 expression has been linked to diseases such as osteoarthritis and osteoporosis, where its altered activity can disrupt normal bone and cartilage formation. Additionally, MAST4's involvement in cellular signaling suggests potential implications in cancer progression, where it may affect tumor cell behavior.
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技术参数
- 靶点基因名
- MAST4
- 基因别名
- KIAA0303
- 蛋白别名
- microtubule associated serine/threonine kinase family member 4; MAST4
- UniProt
- O15021
- 物种
- Human
产品详情
- 靶点名称
- MAST4
- 蛋白名称
- microtubule associated serine/threonine kinase family member 4
- 蛋白别名
- Microtubule-associated serine/threonine-protein kinase 4
- 靶点基因名
- MAST4
- 基因别名
- KIAA0303
- UniProt
- O15021
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) is a serine/threonine kinase that plays a significant role in various cellular processes, particularly in the regulation of cell signaling pathways involved in differentiation and development. MAST4 is primarily associated with microtubules and is implicated in the modulation of cytoskeletal dynamics, influencing cell shape and motility. Research has shown that MAST4 is essential for the differentiation of mesenchymal stem cells (MSCs) into chondrocytes and osteoblasts by mediating signaling pathways such as TGF-β and Wnt. Dysregulation of MAST4 expression has been linked to diseases such as osteoarthritis and osteoporosis, where its altered activity can disrupt normal bone and cartilage formation. Additionally, MAST4's involvement in cellular signaling suggests potential implications in cancer progression, where it may affect tumor cell behavior.