人 MANF 抗体对
01AB00533
Mesencephalic astrocyte derived neurotrophic factor (MANF) is a secreted, evolutionarily conserved protein with neuroprotective and anti-inflammatory properties. Structurally, MANF contains a saposin-like domain and an unstructured C-terminal region, enabling interactions with lipids and proteins like GRP78/BiP, a key chaperone in the endoplasmic reticulum (ER) stress response. MANF is expressed in various tissues, including the brain, pancreas, and immune cells, and functions as a stress-responsive cytoprotective agent by modulating ER homeostasis, reducing oxidative stress, and inhibiting apoptosis. It lacks classical neurotrophic factor receptor binding but exerts its effects through intracellular and extracellular mechanisms, including regulating the unfolded protein response (UPR) and inflammatory pathways. MANF deficiency is implicated in neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases, as well as diabetes, due to its role in pancreatic β-cell survival.
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技术参数
- 靶点基因名
- MANF
- 基因别名
- ARMET; ARP
- 蛋白别名
- mesencephalic astrocyte derived neurotrophic factor; MANF
- UniProt
- P55145
- 物种
- Human
产品详情
- 靶点名称
- MANF
- 蛋白名称
- mesencephalic astrocyte derived neurotrophic factor
- 蛋白别名
- Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET
- 靶点基因名
- MANF
- 基因别名
- ARMET; ARP
- UniProt
- P55145
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Mesencephalic astrocyte derived neurotrophic factor (MANF) is a secreted, evolutionarily conserved protein with neuroprotective and anti-inflammatory properties. Structurally, MANF contains a saposin-like domain and an unstructured C-terminal region, enabling interactions with lipids and proteins like GRP78/BiP, a key chaperone in the endoplasmic reticulum (ER) stress response. MANF is expressed in various tissues, including the brain, pancreas, and immune cells, and functions as a stress-responsive cytoprotective agent by modulating ER homeostasis, reducing oxidative stress, and inhibiting apoptosis. It lacks classical neurotrophic factor receptor binding but exerts its effects through intracellular and extracellular mechanisms, including regulating the unfolded protein response (UPR) and inflammatory pathways. MANF deficiency is implicated in neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases, as well as diabetes, due to its role in pancreatic β-cell survival.