抗人 MAEA 抗体对
01AB00895
Macrophage erythroblast attacher, E3 ubiquitin ligase (MAEA) is a multifunctional protein that serves as a core component of the CTLH E3 ubiquitin-protein ligase complex, selectively accepting ubiquitin from UBE2H to mediate ubiquitination and subsequent proteasomal degradation of transcription factor HBP1. MAEA plays a crucial role in erythropoiesis by mediating the attachment of erythroblasts to macrophages, promoting terminal maturation and enucleation of erythrocytes while inhibiting erythroid cell apoptosis. It participates in erythroblastic island formation, the functional unit of definitive erythropoiesis, and associates with F-actin to regulate actin distribution in erythroblasts and macrophages. Recent studies have shown MAEA is essential for hematopoietic stem cell (HSC) maintenance and lymphoid potential, with its deletion in mice severely impairing HSC quiescence and leading to a lethal myeloproliferative syndrome. MAEA has been associated with several diseases including type 2 diabetes mellitus, various hemoglobinopathies (hemoglobin D and E diseases), hereditary elliptocytosis, myelofibrosis, and cancer.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- MAEA
- 基因别名
- EMP
- 蛋白别名
- macrophage erythroblast attacher, E3 ubiquitin ligase; MAEA
- UniProt
- Q7L5Y9
- 物种
- Human
产品详情
- 靶点名称
- MAEA
- 蛋白名称
- macrophage erythroblast attacher, E3 ubiquitin ligase
- 蛋白别名
- E3 ubiquitin-protein transferase MAEA; Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10; Macrophage erythroblast attacher; P44EMLP
- 靶点基因名
- MAEA
- 基因别名
- EMP
- UniProt
- Q7L5Y9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Macrophage erythroblast attacher, E3 ubiquitin ligase (MAEA) is a multifunctional protein that serves as a core component of the CTLH E3 ubiquitin-protein ligase complex, selectively accepting ubiquitin from UBE2H to mediate ubiquitination and subsequent proteasomal degradation of transcription factor HBP1. MAEA plays a crucial role in erythropoiesis by mediating the attachment of erythroblasts to macrophages, promoting terminal maturation and enucleation of erythrocytes while inhibiting erythroid cell apoptosis. It participates in erythroblastic island formation, the functional unit of definitive erythropoiesis, and associates with F-actin to regulate actin distribution in erythroblasts and macrophages. Recent studies have shown MAEA is essential for hematopoietic stem cell (HSC) maintenance and lymphoid potential, with its deletion in mice severely impairing HSC quiescence and leading to a lethal myeloproliferative syndrome. MAEA has been associated with several diseases including type 2 diabetes mellitus, various hemoglobinopathies (hemoglobin D and E diseases), hereditary elliptocytosis, myelofibrosis, and cancer.