人溶酶体膜蛋白2抗体对
01AB00393
Scavenger receptor class B member 2 (SCARB2) is a type III glycoprotein primarily located in the limiting membranes of lysosomes and endosomes. It is composed of 478 amino acids and belongs to the CD36 family. SCARB2 plays a crucial role in membrane transportation and the reorganization of the endosomal/lysosomal compartment, shuttling between these compartments and the plasma membrane. The protein has a large extracellular domain and short cytoplasmic domains at the amino- and carboxy-terminus. SCARB2 is expressed in various tissues, including neurons in the central nervous system. Deficiencies in SCARB2 have been associated with several diseases, including action myoclonus–renal failure syndrome (AMRF) in humans and ureteric pelvic junction obstruction, deafness, and peripheral neuropathy in mice. Additionally, SCARB2 has been identified as a receptor for Enterovirus 71 (EV71), with a specific 63-amino-acid region encoded in exon 4 of the human SCARB2 gene playing an essential role in EV71 binding and infection.
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技术参数
- 靶点基因名
- SCARB2
- 基因别名
- CD36L2; LIMP2; LIMPII
- 蛋白别名
- scavenger receptor class B member 2; Lysosome Membrane Protein 2
- UniProt
- Q14108
- 物种
- Human
产品详情
- 靶点名称
- Lysosome Membrane Protein 2
- 蛋白名称
- scavenger receptor class B member 2
- 蛋白别名
- Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85; CD36 antigen-like 2; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2; CD antigen CD36
- 靶点基因名
- SCARB2
- 基因别名
- CD36L2; LIMP2; LIMPII
- UniProt
- Q14108
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Scavenger receptor class B member 2 (SCARB2) is a type III glycoprotein primarily located in the limiting membranes of lysosomes and endosomes. It is composed of 478 amino acids and belongs to the CD36 family. SCARB2 plays a crucial role in membrane transportation and the reorganization of the endosomal/lysosomal compartment, shuttling between these compartments and the plasma membrane. The protein has a large extracellular domain and short cytoplasmic domains at the amino- and carboxy-terminus. SCARB2 is expressed in various tissues, including neurons in the central nervous system. Deficiencies in SCARB2 have been associated with several diseases, including action myoclonus–renal failure syndrome (AMRF) in humans and ureteric pelvic junction obstruction, deafness, and peripheral neuropathy in mice. Additionally, SCARB2 has been identified as a receptor for Enterovirus 71 (EV71), with a specific 63-amino-acid region encoded in exon 4 of the human SCARB2 gene playing an essential role in EV71 binding and infection.