抗人 LYSMD3 抗体对
01AB01518
LysM domain containing 3 (LYSMD3) is a type II integral membrane protein characterized by an evolutionarily conserved LysM domain, which is a small globular motif (~40 amino acids) involved in binding peptidoglycan and chitin, common components of bacterial and fungal cell walls. This protein localizes primarily to the Golgi apparatus and plasma membrane, playing a role in Golgi structural integrity and organization. LYSMD3 is widely conserved across species, including humans, mice, zebrafish, flies, and worms, indicating its evolutionary importance. Functionally, LYSMD3 acts as a pattern recognition receptor on epithelial cells, particularly in the human airway, where it binds fungal components such as chitin and β-glucan, mediating inflammatory cytokine responses to fungal spores. Despite its biochemical activity, studies using LysMD3-deficient mice have not demonstrated a clear physiological role in immune defense or intestinal microbiota regulation, suggesting its function may be context-dependent or redundant.
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技术参数
- 靶点基因名
- LYSMD3
- 蛋白别名
- LysM domain containing 3; LYSMD3
- UniProt
- Q7Z3D4
- 物种
- Human
产品详情
- 靶点名称
- LYSMD3
- 蛋白名称
- LysM domain containing 3
- 蛋白别名
- LysM and putative peptidoglycan-binding domain-containing protein 3
- 靶点基因名
- LYSMD3
- UniProt
- Q7Z3D4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
LysM domain containing 3 (LYSMD3) is a type II integral membrane protein characterized by an evolutionarily conserved LysM domain, which is a small globular motif (~40 amino acids) involved in binding peptidoglycan and chitin, common components of bacterial and fungal cell walls. This protein localizes primarily to the Golgi apparatus and plasma membrane, playing a role in Golgi structural integrity and organization. LYSMD3 is widely conserved across species, including humans, mice, zebrafish, flies, and worms, indicating its evolutionary importance. Functionally, LYSMD3 acts as a pattern recognition receptor on epithelial cells, particularly in the human airway, where it binds fungal components such as chitin and β-glucan, mediating inflammatory cytokine responses to fungal spores. Despite its biochemical activity, studies using LysMD3-deficient mice have not demonstrated a clear physiological role in immune defense or intestinal microbiota regulation, suggesting its function may be context-dependent or redundant.