抗人 LYN 抗体对
01AB01218
The LYN proto-oncogene, part of the Src family of tyrosine kinases, encodes a non-receptor tyrosine kinase critical for signal transduction in immune cells. LYN contains SH3, SH2, and catalytic kinase domains, enabling interactions with phosphorylated receptors and downstream signaling molecules. It regulates B-cell receptor (BCR) signaling, myeloid cell differentiation, and innate immune responses via Toll-like receptors (TLRs). Two isoforms, LYN-A and LYN-B, generated by alternative splicing, exhibit distinct cellular localization and functions. LYN activation modulates cell proliferation, survival, and apoptosis. Dysregulation of LYN is implicated in diseases, with a dual role in oncogenesis and autoimmunity. Gain-of-function mutations or overexpression are linked to B-cell malignancies (e.g., chronic lymphocytic leukemia) and myeloid leukemias, while reduced LYN activity contributes to systemic lupus erythematosus (SLE) by impairing B-cell tolerance.
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技术参数
- 靶点基因名
- LYN
- 基因别名
- JTK8
- 蛋白别名
- LYN proto-oncogene, Src family tyrosine kinase; LYN
- UniProt
- P07948
- 物种
- Human
产品详情
- 靶点名称
- LYN
- 蛋白名称
- LYN proto-oncogene, Src family tyrosine kinase
- 蛋白别名
- Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
- 靶点基因名
- LYN
- 基因别名
- JTK8
- UniProt
- P07948
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
The LYN proto-oncogene, part of the Src family of tyrosine kinases, encodes a non-receptor tyrosine kinase critical for signal transduction in immune cells. LYN contains SH3, SH2, and catalytic kinase domains, enabling interactions with phosphorylated receptors and downstream signaling molecules. It regulates B-cell receptor (BCR) signaling, myeloid cell differentiation, and innate immune responses via Toll-like receptors (TLRs). Two isoforms, LYN-A and LYN-B, generated by alternative splicing, exhibit distinct cellular localization and functions. LYN activation modulates cell proliferation, survival, and apoptosis. Dysregulation of LYN is implicated in diseases, with a dual role in oncogenesis and autoimmunity. Gain-of-function mutations or overexpression are linked to B-cell malignancies (e.g., chronic lymphocytic leukemia) and myeloid leukemias, while reduced LYN activity contributes to systemic lupus erythematosus (SLE) by impairing B-cell tolerance.