抗人 LYAR 抗体对
01AB01983
Ly1 antibody reactive (LYAR) is a nucleolar zinc finger protein that plays a dual role in ribosome biogenesis and transcriptional regulation. It facilitates the processing of 47S/45S pre-rRNA into 32S/30S intermediates, thereby promoting the production of 18S and 28S rRNAs essential for cell growth. Additionally, LYAR acts as a transcriptional repressor and a negative regulator of innate antiviral signaling by binding to phosphorylated IRF3, which inhibits the expression of interferon-β and NF-κB-driven cytokines. Clinically, LYAR is significantly upregulated in various malignancies, including neuroblastoma and colorectal cancer, where it correlates with aggressive tumor behavior and poor prognosis. It is also implicated in the regulation of γ-globin expression, linking it to the pathophysiology of β-thalassemia.
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技术参数
- 靶点基因名
- LYAR
- 蛋白别名
- Ly1 antibody reactive; LYAR
- UniProt
- Q9NX58
- 物种
- Human
产品详情
- 靶点名称
- LYAR
- 蛋白名称
- Ly1 antibody reactive
- 蛋白别名
- Cell growth-regulating nucleolar protein
- 靶点基因名
- LYAR
- UniProt
- Q9NX58
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ly1 antibody reactive (LYAR) is a nucleolar zinc finger protein that plays a dual role in ribosome biogenesis and transcriptional regulation. It facilitates the processing of 47S/45S pre-rRNA into 32S/30S intermediates, thereby promoting the production of 18S and 28S rRNAs essential for cell growth. Additionally, LYAR acts as a transcriptional repressor and a negative regulator of innate antiviral signaling by binding to phosphorylated IRF3, which inhibits the expression of interferon-β and NF-κB-driven cytokines. Clinically, LYAR is significantly upregulated in various malignancies, including neuroblastoma and colorectal cancer, where it correlates with aggressive tumor behavior and poor prognosis. It is also implicated in the regulation of γ-globin expression, linking it to the pathophysiology of β-thalassemia.