抗人 LURAP1 抗体对
01AB01981
Leucine rich adaptor protein 1 (LURAP1) is a cytosolic adaptor protein that plays a key role in activating the canonical NF-κB signaling pathway. By driving the production of pro-inflammatory cytokines, it enhances the antigen-presenting and T-cell priming capabilities of dendritic cells. Additionally, LURAP1 forms a functional complex with MYO18A and CDC42BPA/B to regulate lamellar actomyosin retrograde flow. This mechanism promotes cell protrusion and migration through the phosphorylation of MYL9/MLC2 and the assembly of MYH9/MYH10-dependent actomyosin structures. LURAP1 is widely expressed across human tissues and localizes to the cytosol and intracellular membrane-bounded organelles. Its dual involvement in immune signaling and cytoskeletal dynamics underscores its importance in inflammatory responses and cellular motility, making it a central mediator of both innate immunity and structural cell biology.
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技术参数
- 靶点基因名
- LURAP1
- 基因别名
- C1orf190; LRAP35A; LRP35A
- 蛋白别名
- leucine rich adaptor protein 1; LURAP1
- UniProt
- Q96LR2
- 物种
- Human
产品详情
- 靶点名称
- LURAP1
- 蛋白名称
- leucine rich adaptor protein 1
- 蛋白别名
- Leucine rich adaptor protein 1; Leucine repeat adapter protein 35A
- 靶点基因名
- LURAP1
- 基因别名
- C1orf190; LRAP35A; LRP35A
- UniProt
- Q96LR2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich adaptor protein 1 (LURAP1) is a cytosolic adaptor protein that plays a key role in activating the canonical NF-κB signaling pathway. By driving the production of pro-inflammatory cytokines, it enhances the antigen-presenting and T-cell priming capabilities of dendritic cells. Additionally, LURAP1 forms a functional complex with MYO18A and CDC42BPA/B to regulate lamellar actomyosin retrograde flow. This mechanism promotes cell protrusion and migration through the phosphorylation of MYL9/MLC2 and the assembly of MYH9/MYH10-dependent actomyosin structures. LURAP1 is widely expressed across human tissues and localizes to the cytosol and intracellular membrane-bounded organelles. Its dual involvement in immune signaling and cytoskeletal dynamics underscores its importance in inflammatory responses and cellular motility, making it a central mediator of both innate immunity and structural cell biology.