人 LRRN1 抗体对
01AB00297
Leucine rich repeat neuronal 1 (LRRN1) is a protein encoded by the LRRN1 gene in humans. It is a single-pass, transmembrane protein characterized by leucine-rich repeats, which are known to be involved in various cellular processes including cell-cell interactions and signaling pathways. LRRN1 has been implicated in several biological processes, including the regulation of boundary formation and cellular patterning during development, particularly in the organ of Corti in the mammalian cochlea. It interacts with the Notch signaling pathway to enhance Notch activity, which is crucial for the proper formation of sensory and nonsensory regions in the cochlea. Additionally, LRRN1 has been associated with the suppression of apoptosis in gastric cancer cells through the regulation of Fas/FasL. Its role in neuroblastoma and neuronal development as an extracellular negative regulator of ALK signaling has also been noted.
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技术参数
- 靶点基因名
- LRRN1
- 基因别名
- KIAA1497
- 蛋白别名
- leucine rich repeat neuronal 1; LRRN1
- UniProt
- Q6UXK5
- 物种
- Human
产品详情
- 靶点名称
- LRRN1
- 蛋白名称
- leucine rich repeat neuronal 1
- 蛋白别名
- Leucine-rich repeat neuronal protein 1; Neuronal leucine-rich repeat protein 1; NLRR-1
- 靶点基因名
- LRRN1
- 基因别名
- KIAA1497
- UniProt
- Q6UXK5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat neuronal 1 (LRRN1) is a protein encoded by the LRRN1 gene in humans. It is a single-pass, transmembrane protein characterized by leucine-rich repeats, which are known to be involved in various cellular processes including cell-cell interactions and signaling pathways. LRRN1 has been implicated in several biological processes, including the regulation of boundary formation and cellular patterning during development, particularly in the organ of Corti in the mammalian cochlea. It interacts with the Notch signaling pathway to enhance Notch activity, which is crucial for the proper formation of sensory and nonsensory regions in the cochlea. Additionally, LRRN1 has been associated with the suppression of apoptosis in gastric cancer cells through the regulation of Fas/FasL. Its role in neuroblastoma and neuronal development as an extracellular negative regulator of ALK signaling has also been noted.