人 LRRFIP2 抗体对
01AB02211
LRR binding FLII interacting protein 2 (LRRFIP2) is a multifunctional protein characterized by leucine-rich repeat (LRR) domains, which facilitate protein-protein interactions and are implicated in the regulation of several signaling pathways, notably the canonical Wnt/β-catenin pathway, where LRRFIP2 may act as an activator upstream of β-catenin. Structurally, LRRFIP2 shares significant sequence homology with LRRFIP1 and is known to interact with the LRR domain of flightless I homolog (Fliih), modulating innate immune responses by disrupting the MyD88-Fliih interaction during Toll-like receptor (TLR) signaling, particularly upon lipopolysaccharide (LPS) stimulation. The protein is also involved in regulating transcriptional activity and has multiple expressed variants across vertebrates and invertebrates.
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技术参数
- 靶点基因名
- LRRFIP2
- 蛋白别名
- LRR binding FLII interacting protein 2; LRRFIP2
- UniProt
- Q9Y608
- 物种
- Human
产品详情
- 靶点名称
- LRRFIP2
- 蛋白名称
- LRR binding FLII interacting protein 2
- 蛋白别名
- Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2
- 靶点基因名
- LRRFIP2
- UniProt
- Q9Y608
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
LRR binding FLII interacting protein 2 (LRRFIP2) is a multifunctional protein characterized by leucine-rich repeat (LRR) domains, which facilitate protein-protein interactions and are implicated in the regulation of several signaling pathways, notably the canonical Wnt/β-catenin pathway, where LRRFIP2 may act as an activator upstream of β-catenin. Structurally, LRRFIP2 shares significant sequence homology with LRRFIP1 and is known to interact with the LRR domain of flightless I homolog (Fliih), modulating innate immune responses by disrupting the MyD88-Fliih interaction during Toll-like receptor (TLR) signaling, particularly upon lipopolysaccharide (LPS) stimulation. The protein is also involved in regulating transcriptional activity and has multiple expressed variants across vertebrates and invertebrates.