抗人 LRRC4C 抗体对
01AB01211
Leucine rich repeat containing 4C (LRRC4C), also known as NGL-1, is a type I transmembrane protein predominantly expressed in the brain, especially in the cerebral cortex (frontal, parietal, occipital lobes), with moderate expression in regions like the hippocampus and amygdala. Structurally, it contains nine leucine-rich repeats flanked by N- and C-terminal LRR domains and an Ig-like C2-type domain in its extracellular region, and a cytoplasmic tail with a PDZ-binding motif, facilitating interactions with postsynaptic density proteins. LRRC4C functions as a synaptic adhesion molecule binding specifically to netrin-G1, promoting neurite outgrowth and synapse formation, particularly in thalamocortical axons, thus playing a critical role in synaptic organization and plasticity in the developing brain. Disease associations include developmental and epileptic encephalopathy and autism spectrum disorder, with evidence suggesting that disruptions in LRRC4C contribute to neurodevelopmental disorders by impairing synaptic connectivity and neural circuit formation.
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技术参数
- 靶点基因名
- LRRC4C
- 基因别名
- KIAA1580; NGL1
- 蛋白别名
- leucine rich repeat containing 4C; LRRC4C
- UniProt
- Q9HCJ2
- 物种
- Human
产品详情
- 靶点名称
- LRRC4C
- 蛋白名称
- leucine rich repeat containing 4C
- 蛋白别名
- Leucine-rich repeat-containing protein 4C; Netrin-G1 ligand; NGL-1
- 靶点基因名
- LRRC4C
- 基因别名
- KIAA1580; NGL1
- UniProt
- Q9HCJ2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat containing 4C (LRRC4C), also known as NGL-1, is a type I transmembrane protein predominantly expressed in the brain, especially in the cerebral cortex (frontal, parietal, occipital lobes), with moderate expression in regions like the hippocampus and amygdala. Structurally, it contains nine leucine-rich repeats flanked by N- and C-terminal LRR domains and an Ig-like C2-type domain in its extracellular region, and a cytoplasmic tail with a PDZ-binding motif, facilitating interactions with postsynaptic density proteins. LRRC4C functions as a synaptic adhesion molecule binding specifically to netrin-G1, promoting neurite outgrowth and synapse formation, particularly in thalamocortical axons, thus playing a critical role in synaptic organization and plasticity in the developing brain. Disease associations include developmental and epileptic encephalopathy and autism spectrum disorder, with evidence suggesting that disruptions in LRRC4C contribute to neurodevelopmental disorders by impairing synaptic connectivity and neural circuit formation.