抗人 LRRC4 抗体对
01AB00884
Leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand 2 (NGL-2), is a synaptic adhesion protein highly expressed in the brain. It plays a crucial role in regulating the formation of excitatory synapses by recruiting pre- and post-synaptic proteins. LRRC4 is a member of the partitioning-defective protein (PAR) polarity complex, promoting axon differentiation and mediating synaptic plasticity. It contains extracellular leucine-rich repeat domains, an immunoglobulin C2 domain, a transmembrane domain, and a PDZ-binding domain in the cytoplasm. LRRC4 is involved in organizing lamina-specific dendrite differentiation and auditory synaptic responses. In terms of disease associations, LRRC4 has been identified as a candidate susceptibility gene for autism and a neuroprotective factor in spinal nerve damage. Additionally, it functions as a tumor suppressor gene in gliomas, with its expression negatively correlated with glioma malignancy.
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技术参数
- 靶点基因名
- LRRC4
- 基因别名
- BAG
- 蛋白别名
- leucine rich repeat containing 4; LRRC4
- UniProt
- Q9HBW1
- 物种
- Human
产品详情
- 靶点名称
- LRRC4
- 蛋白名称
- leucine rich repeat containing 4
- 蛋白别名
- Leucine-rich repeat-containing protein 4; Brain tumor-associated protein BAG; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2
- 靶点基因名
- LRRC4
- 基因别名
- BAG
- UniProt
- Q9HBW1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand 2 (NGL-2), is a synaptic adhesion protein highly expressed in the brain. It plays a crucial role in regulating the formation of excitatory synapses by recruiting pre- and post-synaptic proteins. LRRC4 is a member of the partitioning-defective protein (PAR) polarity complex, promoting axon differentiation and mediating synaptic plasticity. It contains extracellular leucine-rich repeat domains, an immunoglobulin C2 domain, a transmembrane domain, and a PDZ-binding domain in the cytoplasm. LRRC4 is involved in organizing lamina-specific dendrite differentiation and auditory synaptic responses. In terms of disease associations, LRRC4 has been identified as a candidate susceptibility gene for autism and a neuroprotective factor in spinal nerve damage. Additionally, it functions as a tumor suppressor gene in gliomas, with its expression negatively correlated with glioma malignancy.