人 LRRC38 抗体对
01AB03458
Leucine rich repeat containing 38 (LRRC38) is a single-pass transmembrane protein that functions as an auxiliary gamma-4 subunit of the large-conductance, voltage- and calcium-activated potassium (BK) channel. It is characterized by an extracellular leucine-rich repeat domain that facilitates essential protein-protein interactions within the channel complex. LRRC38 modulates BK channel gating by significantly shifting the voltage dependence of activation in the hyperpolarizing direction. This modulation allows the channel to open at lower calcium concentrations and more negative membrane potentials, which is particularly critical for regulating membrane excitability in non-excitable cells and secretory glands. The protein is prominently expressed in the adrenal gland, prostate, skeletal muscle, and thymus. By acting as a positive regulator of voltage-gated potassium channel activity, LRRC38 plays a vital role in fine-tuning potassium transport and cellular homeostasis across various tissues.
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技术参数
- 靶点基因名
- LRRC38
- 蛋白别名
- leucine rich repeat containing 38; LRRC38
- UniProt
- Q5VT99
- 物种
- Human
产品详情
- 靶点名称
- LRRC38
- 蛋白名称
- leucine rich repeat containing 38
- 蛋白别名
- Leucine-rich repeat-containing protein 38; BK channel auxiliary gamma subunit LRRC38
- 靶点基因名
- LRRC38
- UniProt
- Q5VT99
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat containing 38 (LRRC38) is a single-pass transmembrane protein that functions as an auxiliary gamma-4 subunit of the large-conductance, voltage- and calcium-activated potassium (BK) channel. It is characterized by an extracellular leucine-rich repeat domain that facilitates essential protein-protein interactions within the channel complex. LRRC38 modulates BK channel gating by significantly shifting the voltage dependence of activation in the hyperpolarizing direction. This modulation allows the channel to open at lower calcium concentrations and more negative membrane potentials, which is particularly critical for regulating membrane excitability in non-excitable cells and secretory glands. The protein is prominently expressed in the adrenal gland, prostate, skeletal muscle, and thymus. By acting as a positive regulator of voltage-gated potassium channel activity, LRRC38 plays a vital role in fine-tuning potassium transport and cellular homeostasis across various tissues.