人 LRP11 抗体对
01AB00876
LDL receptor related protein 11 (LRP11) is a 500-amino acid single-pass type I membrane glycoprotein belonging to the LDLR family. It exists in two alternatively spliced isoforms with molecular weights of 60 and 35 kDa. LRP11 enables phosphoprotein binding activity and is predicted to be involved in responses to cold, immobilization stress, and water deprivation. The protein is primarily located in the plasma membrane. LRP11 shares 67% amino acid identity with mouse LRP11 over residues 38-450. In terms of disease associations, LRP11 has been implicated in cervical cancer progression. Higher expression of LRP11 has been observed in high-grade squamous intraepithelial lesions and cervical cancer tissues compared to normal cervix. LRP11 silencing in cervical cancer cell lines inhibited proliferation, migration, and invasion.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- LRP11
- 蛋白别名
- LDL receptor related protein 11; LRP11
- UniProt
- Q86VZ4
- 物种
- Human
产品详情
- 靶点名称
- LRP11
- 蛋白名称
- LDL receptor related protein 11
- 蛋白别名
- Low-density lipoprotein receptor-related protein 11; LRP-11
- 靶点基因名
- LRP11
- UniProt
- Q86VZ4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
LDL receptor related protein 11 (LRP11) is a 500-amino acid single-pass type I membrane glycoprotein belonging to the LDLR family. It exists in two alternatively spliced isoforms with molecular weights of 60 and 35 kDa. LRP11 enables phosphoprotein binding activity and is predicted to be involved in responses to cold, immobilization stress, and water deprivation. The protein is primarily located in the plasma membrane. LRP11 shares 67% amino acid identity with mouse LRP11 over residues 38-450. In terms of disease associations, LRP11 has been implicated in cervical cancer progression. Higher expression of LRP11 has been observed in high-grade squamous intraepithelial lesions and cervical cancer tissues compared to normal cervix. LRP11 silencing in cervical cancer cell lines inhibited proliferation, migration, and invasion.