抗人 LRIG3 抗体对
01AB01207
Leucine rich repeats and immunoglobulin like domains 3 (LRIG3) is a single-pass transmembrane protein that belongs to the LRIG family. It contains a putative signal peptide, leucine-rich repeat domains, immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. LRIG3 is primarily localized in the cell membrane and Golgi apparatus, with some punctate distribution in the cytosol. It is expressed in various tissues, including the brain, inner ear, and craniofacial regions during embryonic development. LRIG3 plays a role in modulating FGF and Wnt signaling pathways, and it can interact with and regulate FGFR1 levels. In terms of disease associations, LRIG3 has been implicated in cancer progression, particularly in gliomas. It may function as a tumor suppressor by inhibiting cell proliferation, survival, and invasion through negative regulation of the EGFR signaling pathway.
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技术参数
- 靶点基因名
- LRIG3
- 基因别名
- LIG3
- 蛋白别名
- leucine rich repeats and immunoglobulin like domains 3; LRIG3
- UniProt
- Q6UXM1
- 物种
- Human
产品详情
- 靶点名称
- LRIG3
- 蛋白名称
- leucine rich repeats and immunoglobulin like domains 3
- 蛋白别名
- Leucine-rich repeats and immunoglobulin-like domains protein 3; LIG-3
- 靶点基因名
- LRIG3
- 基因别名
- LIG3
- UniProt
- Q6UXM1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeats and immunoglobulin like domains 3 (LRIG3) is a single-pass transmembrane protein that belongs to the LRIG family. It contains a putative signal peptide, leucine-rich repeat domains, immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. LRIG3 is primarily localized in the cell membrane and Golgi apparatus, with some punctate distribution in the cytosol. It is expressed in various tissues, including the brain, inner ear, and craniofacial regions during embryonic development. LRIG3 plays a role in modulating FGF and Wnt signaling pathways, and it can interact with and regulate FGFR1 levels. In terms of disease associations, LRIG3 has been implicated in cancer progression, particularly in gliomas. It may function as a tumor suppressor by inhibiting cell proliferation, survival, and invasion through negative regulation of the EGFR signaling pathway.