抗人 LRFN3 抗体对
01AB01203
Leucine rich repeat and fibronectin type III domain containing 3 (LRFN3) is a cell adhesion molecule characterized by leucine-rich repeat (LRR) and fibronectin type III domains, which are known to mediate protein-protein interactions crucial for cellular communication and structural integrity. LRFN3 facilitates homophilic cell-cell adhesion in a calcium-independent manner and is particularly important in the nervous system, where it promotes neurite outgrowth in hippocampal neurons and is predicted to regulate presynapse assembly and synaptic membrane adhesion, supporting the development and maintenance of synaptic connections. Expression data show LRFN3 is highly enriched in brain regions, underscoring its role in neural tissue. Disruptions in synaptic adhesion molecules like LRFN3 are increasingly recognized as contributing factors in neurodevelopmental and neuropsychiatric disorders, suggesting that LRFN3 dysfunction may impact brain connectivity and function.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- LRFN3
- 基因别名
- SALM4
- 蛋白别名
- leucine rich repeat and fibronectin type III domain containing 3; LRFN3
- UniProt
- Q9BTN0
- 物种
- Human
产品详情
- 靶点名称
- LRFN3
- 蛋白名称
- leucine rich repeat and fibronectin type III domain containing 3
- 蛋白别名
- Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Synaptic adhesion-like molecule 4
- 靶点基因名
- LRFN3
- 基因别名
- SALM4
- UniProt
- Q9BTN0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat and fibronectin type III domain containing 3 (LRFN3) is a cell adhesion molecule characterized by leucine-rich repeat (LRR) and fibronectin type III domains, which are known to mediate protein-protein interactions crucial for cellular communication and structural integrity. LRFN3 facilitates homophilic cell-cell adhesion in a calcium-independent manner and is particularly important in the nervous system, where it promotes neurite outgrowth in hippocampal neurons and is predicted to regulate presynapse assembly and synaptic membrane adhesion, supporting the development and maintenance of synaptic connections. Expression data show LRFN3 is highly enriched in brain regions, underscoring its role in neural tissue. Disruptions in synaptic adhesion molecules like LRFN3 are increasingly recognized as contributing factors in neurodevelopmental and neuropsychiatric disorders, suggesting that LRFN3 dysfunction may impact brain connectivity and function.