抗人 LRFN1 抗体对
01AB01198
Leucine rich repeat and fibronectin type III domain containing 1 (LRFN1) is a membrane-associated protein predominantly expressed in the brain, especially in hippocampal neurons, where it promotes neurite outgrowth and is crucial for the regulation and maintenance of excitatory synapses. Structurally, LRFN1 contains leucine-rich repeats and fibronectin type III domains, which facilitate protein-protein interactions essential for synaptic assembly. It induces clustering of key postsynaptic proteins such as DLG4, DLGAP1, GRIA1, and GRIN1, thereby contributing to postsynaptic density organization and synaptic plasticity. Clinically, mutations or dysregulation of LRFN1 have been associated with neurological disorders, notably familial temporal lobe epilepsy, reflecting its role in synaptic function and neuronal excitability.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- LRFN1
- 基因别名
- KIAA1484; SALM2
- 蛋白别名
- leucine rich repeat and fibronectin type III domain containing 1; LRFN1
- UniProt
- Q9P244
- 物种
- Human
产品详情
- 靶点名称
- LRFN1
- 蛋白名称
- leucine rich repeat and fibronectin type III domain containing 1
- 蛋白别名
- Leucine-rich repeat and fibronectin type III domain-containing protein 1; Synaptic adhesion-like molecule 2
- 靶点基因名
- LRFN1
- 基因别名
- KIAA1484; SALM2
- UniProt
- Q9P244
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leucine rich repeat and fibronectin type III domain containing 1 (LRFN1) is a membrane-associated protein predominantly expressed in the brain, especially in hippocampal neurons, where it promotes neurite outgrowth and is crucial for the regulation and maintenance of excitatory synapses. Structurally, LRFN1 contains leucine-rich repeats and fibronectin type III domains, which facilitate protein-protein interactions essential for synaptic assembly. It induces clustering of key postsynaptic proteins such as DLG4, DLGAP1, GRIA1, and GRIN1, thereby contributing to postsynaptic density organization and synaptic plasticity. Clinically, mutations or dysregulation of LRFN1 have been associated with neurological disorders, notably familial temporal lobe epilepsy, reflecting its role in synaptic function and neuronal excitability.