人肝脏 Carboxylesterase 1 抗体对
01AB00182
Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases responsible for the hydrolysis of ester and amide bonds. It has broad substrate specificity, ranging from small molecule esters to long chain fatty acid esters and thioesters, and plays a major role in the pharmacokinetic behavior of therapeutic agents containing ester bonds. The protein is expressed in various tissues, including the liver, and its deficiency can lead to altered drug metabolism. CES1 is involved in the detoxification of drugs such as cocaine and heroin in serum and liver, and it can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents. Deficiency in CES1 has been associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia.
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技术参数
- 靶点基因名
- CES1
- 基因别名
- CES2; SES1
- 蛋白别名
- carboxylesterase 1; Liver Carboxylesterase 1
- UniProt
- P23141
- 物种
- Human
产品详情
- 靶点名称
- Liver Carboxylesterase 1
- 蛋白名称
- carboxylesterase 1
- 蛋白别名
- Liver carboxylesterase 1; Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; Cholesteryl ester hydrolase; CEH; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1; Monocyte/macrophage serine esterase; Retinyl ester hydrolase; REH; Serine esterase 1; Triacylglycerol hydrolase; TGH
- 靶点基因名
- CES1
- 基因别名
- CES2; SES1
- UniProt
- P23141
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases responsible for the hydrolysis of ester and amide bonds. It has broad substrate specificity, ranging from small molecule esters to long chain fatty acid esters and thioesters, and plays a major role in the pharmacokinetic behavior of therapeutic agents containing ester bonds. The protein is expressed in various tissues, including the liver, and its deficiency can lead to altered drug metabolism. CES1 is involved in the detoxification of drugs such as cocaine and heroin in serum and liver, and it can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents. Deficiency in CES1 has been associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia.