人 LIMCH1 抗体对
01AB02849
LIM and calponin homology domains 1 (LIMCH1) is an actin stress fiber-associated protein characterized by an N-terminal calponin homology (CH) domain, a C-terminal LIM domain, and central coiled-coil regions. The CH domain facilitates actin binding, while the LIM domain mediates protein interactions. LIMCH1 regulates the activity of non-muscle myosin IIa (NM-IIA) by promoting phosphorylation of myosin regulatory light chain (MRLC), enhancing actomyosin contractility and stress fiber assembly. This function stabilizes focal adhesions and modulates cell morphology and motility. LIMCH1 depletion reduces MRLC phosphorylation, disrupts stress fibers, and decreases focal adhesion stability, leading to increased cell spreading and migration, indicating its role in restricting cell motility. In disease contexts, alterations in LIMCH1 expression may influence cancer cell migration and metastasis.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- LIMCH1
- 基因别名
- KIAA1102
- 蛋白别名
- LIM and calponin homology domains 1; LIMCH1
- UniProt
- Q9UPQ0
- 物种
- Human
产品详情
- 靶点名称
- LIMCH1
- 蛋白名称
- LIM and calponin homology domains 1
- 蛋白别名
- LIM and calponin homology domains-containing protein 1
- 靶点基因名
- LIMCH1
- 基因别名
- KIAA1102
- UniProt
- Q9UPQ0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
LIM and calponin homology domains 1 (LIMCH1) is an actin stress fiber-associated protein characterized by an N-terminal calponin homology (CH) domain, a C-terminal LIM domain, and central coiled-coil regions. The CH domain facilitates actin binding, while the LIM domain mediates protein interactions. LIMCH1 regulates the activity of non-muscle myosin IIa (NM-IIA) by promoting phosphorylation of myosin regulatory light chain (MRLC), enhancing actomyosin contractility and stress fiber assembly. This function stabilizes focal adhesions and modulates cell morphology and motility. LIMCH1 depletion reduces MRLC phosphorylation, disrupts stress fibers, and decreases focal adhesion stability, leading to increased cell spreading and migration, indicating its role in restricting cell motility. In disease contexts, alterations in LIMCH1 expression may influence cancer cell migration and metastasis.