抗人 LIMA1 抗体对
01AB01511
LIM domain and actin binding 1 (LIMA1), also known as EPLIN or SREBP3, is a cytoskeleton-associated protein that plays a crucial role in regulating actin filament dynamics. It contains a central LIM domain and multiple actin-binding domains at its ends, enabling it to cross-link and stabilize actin filaments, increase the number and size of actin stress fibers, and inhibit actin filament depolymerization and membrane ruffling. LIMA1 exists in two isoforms, LIMA1-α and LIMA1-β, and can dimerize or interact with other proteins via its LIM domain. By stabilizing the actin network and inhibiting Arp2/3-mediated actin nucleation, LIMA1 is essential for maintaining cytoskeletal integrity and cadherin-mediated cell adhesion. Loss or deficiency of LIMA1 disrupts cytoskeletal dynamics, cell motility, and cell-cell adhesion, which can enhance tumor cell proliferation, invasion, and migration.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- LIMA1
- 基因别名
- EPLIN; SREBP3
- 蛋白别名
- LIM domain and actin binding 1; LIMA1
- UniProt
- Q9UHB6
- 物种
- Human
产品详情
- 靶点名称
- LIMA1
- 蛋白名称
- LIM domain and actin binding 1
- 蛋白别名
- LIM domain and actin-binding protein 1; Epithelial protein lost in neoplasm
- 靶点基因名
- LIMA1
- 基因别名
- EPLIN; SREBP3
- UniProt
- Q9UHB6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
LIM domain and actin binding 1 (LIMA1), also known as EPLIN or SREBP3, is a cytoskeleton-associated protein that plays a crucial role in regulating actin filament dynamics. It contains a central LIM domain and multiple actin-binding domains at its ends, enabling it to cross-link and stabilize actin filaments, increase the number and size of actin stress fibers, and inhibit actin filament depolymerization and membrane ruffling. LIMA1 exists in two isoforms, LIMA1-α and LIMA1-β, and can dimerize or interact with other proteins via its LIM domain. By stabilizing the actin network and inhibiting Arp2/3-mediated actin nucleation, LIMA1 is essential for maintaining cytoskeletal integrity and cadherin-mediated cell adhesion. Loss or deficiency of LIMA1 disrupts cytoskeletal dynamics, cell motility, and cell-cell adhesion, which can enhance tumor cell proliferation, invasion, and migration.