人 LILRB1 抗体对
01AB00872
Leukocyte immunoglobulin like receptor B1 (LILRB1) is an inhibitory receptor expressed on various immune cells, including myeloid cells, NK cells, and subsets of T and B cells. It contains four extracellular immunoglobulin-like domains and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 binds to MHC class I molecules, including HLA-G, and transduces negative signals that suppress immune responses and cytotoxicity. Upon activation, LILRB1 recruits phosphatases like SHP-1 and CSK, which dephosphorylate key kinases involved in immune cell activation. LILRB1 plays crucial roles in immune tolerance, regulating phagocytosis, and modulating NK cell and T cell functions. In pathological conditions, LILRB1 has been implicated in cancer progression, where its expression on NK cells correlates with decreased cytotoxicity in breast cancer. Additionally, some pathogens exploit LILRB1 to evade immune responses.
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技术参数
- 靶点基因名
- LILRB1
- 基因别名
- ILT2; LIR1; MIR7
- 蛋白别名
- leukocyte immunoglobulin like receptor B1; LILRB1
- UniProt
- Q8NHL6
- 物种
- Human
产品详情
- 靶点名称
- LILRB1
- 蛋白名称
- leukocyte immunoglobulin like receptor B1
- 蛋白别名
- Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD antigen CD85j
- 靶点基因名
- LILRB1
- 基因别名
- ILT2; LIR1; MIR7
- UniProt
- Q8NHL6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leukocyte immunoglobulin like receptor B1 (LILRB1) is an inhibitory receptor expressed on various immune cells, including myeloid cells, NK cells, and subsets of T and B cells. It contains four extracellular immunoglobulin-like domains and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 binds to MHC class I molecules, including HLA-G, and transduces negative signals that suppress immune responses and cytotoxicity. Upon activation, LILRB1 recruits phosphatases like SHP-1 and CSK, which dephosphorylate key kinases involved in immune cell activation. LILRB1 plays crucial roles in immune tolerance, regulating phagocytosis, and modulating NK cell and T cell functions. In pathological conditions, LILRB1 has been implicated in cancer progression, where its expression on NK cells correlates with decreased cytotoxicity in breast cancer. Additionally, some pathogens exploit LILRB1 to evade immune responses.