人 LILRA5 抗体对
01AB00866
Leukocyte immunoglobulin like receptor A5 (LILRA5) is a member of the LIR family, which regulates leukocyte activation and innate immune responses. It exists in membrane-bound and soluble forms, with the transmembrane variant containing a short cytoplasmic domain and a charged arginine residue. LILRA5 cross-linking on monocytes induces calcium flux and secretion of pro-inflammatory cytokines, including IL-10, highlighting its role in inflammation. It interacts with signaling molecules such as Src tyrosine kinases and Spleen tyrosine kinase (Syk), contributing to immune regulation. The receptor is encoded by the LILRA5 gene located on chromosome 19q13.4, with multiple transcript variants reported. LILRA5 expression is elevated in synovial tissue macrophages and synovial fluid in rheumatoid arthritis (RA) but not osteoarthritis, suggesting its involvement in RA pathogenesis.
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技术参数
- 靶点基因名
- LILRA5
- 基因别名
- ILT11; LILRB7; LIR9
- 蛋白别名
- leukocyte immunoglobulin like receptor A5; LILRA5
- UniProt
- A6NI73
- 物种
- Human
产品详情
- 靶点名称
- LILRA5
- 蛋白名称
- leukocyte immunoglobulin like receptor A5
- 蛋白别名
- Leukocyte immunoglobulin-like receptor subfamily A member 5; CD85 antigen-like family member F; Immunoglobulin-like transcript 11; ILT-11; Leukocyte immunoglobulin-like receptor 9; LIR-9; CD antigen CD85f
- 靶点基因名
- LILRA5
- 基因别名
- ILT11; LILRB7; LIR9
- UniProt
- A6NI73
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leukocyte immunoglobulin like receptor A5 (LILRA5) is a member of the LIR family, which regulates leukocyte activation and innate immune responses. It exists in membrane-bound and soluble forms, with the transmembrane variant containing a short cytoplasmic domain and a charged arginine residue. LILRA5 cross-linking on monocytes induces calcium flux and secretion of pro-inflammatory cytokines, including IL-10, highlighting its role in inflammation. It interacts with signaling molecules such as Src tyrosine kinases and Spleen tyrosine kinase (Syk), contributing to immune regulation. The receptor is encoded by the LILRA5 gene located on chromosome 19q13.4, with multiple transcript variants reported. LILRA5 expression is elevated in synovial tissue macrophages and synovial fluid in rheumatoid arthritis (RA) but not osteoarthritis, suggesting its involvement in RA pathogenesis.