人 LIFR 抗体对
01AB04081
Leukemia inhibitory factor receptor (LIFR), also known as CD118, is a transmembrane protein that functions as a receptor for leukemia inhibitory factor (LIF) and other related cytokines. It is part of the cytokine receptor family and plays a crucial role in various biological processes, including cell differentiation, proliferation, and survival. LIFR forms a signaling complex with glycoprotein 130 (gp130), which enhances its signaling capabilities. Dysregulation of LIFR has been linked to several diseases, most notably Stüve-Wiedemann syndrome, characterized by skeletal abnormalities and respiratory issues due to impaired signaling pathways. Additionally, LIFR has been implicated in cancer biology, where it acts as a metastasis suppressor in breast cancer.
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技术参数
- 靶点基因名
- LIFR
- 蛋白别名
- LIF receptor subunit alpha; LIFR
- UniProt
- P42702
- 物种
- Human
产品详情
- 靶点名称
- LIFR
- 蛋白名称
- LIF receptor subunit alpha
- 蛋白别名
- Leukemia inhibitory factor receptor; LIF receptor; LIF-R; CD antigen CD118
- 靶点基因名
- LIFR
- UniProt
- P42702
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leukemia inhibitory factor receptor (LIFR), also known as CD118, is a transmembrane protein that functions as a receptor for leukemia inhibitory factor (LIF) and other related cytokines. It is part of the cytokine receptor family and plays a crucial role in various biological processes, including cell differentiation, proliferation, and survival. LIFR forms a signaling complex with glycoprotein 130 (gp130), which enhances its signaling capabilities. Dysregulation of LIFR has been linked to several diseases, most notably Stüve-Wiedemann syndrome, characterized by skeletal abnormalities and respiratory issues due to impaired signaling pathways. Additionally, LIFR has been implicated in cancer biology, where it acts as a metastasis suppressor in breast cancer.