人 LHB 抗体对
01AB01751
Luteinizing hormone subunit beta (LHB) is the hormone-specific beta chain of luteinizing hormone (LH), a pituitary glycoprotein essential for reproductive function. It heterodimerizes with a common alpha-subunit to form bioactive LH, which signals through the LH receptor (LHCGR) to regulate gonadal steroidogenesis, ovulation in females, and testosterone production by Leydig cells in males. The LHB subunit features a stable cystine-knot fold and a characteristic seatbelt region that secures the heterodimeric complex. Clinically, pathogenic variants in the LHB gene lead to isolated LH deficiency, a condition characterized by hypogonadotropic hypogonadism. Affected individuals typically present with delayed or absent puberty, infertility, and low sex steroid levels, resulting in anovulation in females and impaired spermatogenesis in males. Disruption of the LH signaling axis is also a recognized cause of Leydig cell hypoplasia and various forms of male pseudohermaphroditism.
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技术参数
- 靶点基因名
- LHB
- 蛋白别名
- luteinizing hormone subunit beta; LHB
- UniProt
- P01229
- 物种
- Human
产品详情
- 靶点名称
- LHB
- 蛋白名称
- luteinizing hormone subunit beta
- 蛋白别名
- Lutropin subunit beta; Lutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta
- 靶点基因名
- LHB
- UniProt
- P01229
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Luteinizing hormone subunit beta (LHB) is the hormone-specific beta chain of luteinizing hormone (LH), a pituitary glycoprotein essential for reproductive function. It heterodimerizes with a common alpha-subunit to form bioactive LH, which signals through the LH receptor (LHCGR) to regulate gonadal steroidogenesis, ovulation in females, and testosterone production by Leydig cells in males. The LHB subunit features a stable cystine-knot fold and a characteristic seatbelt region that secures the heterodimeric complex. Clinically, pathogenic variants in the LHB gene lead to isolated LH deficiency, a condition characterized by hypogonadotropic hypogonadism. Affected individuals typically present with delayed or absent puberty, infertility, and low sex steroid levels, resulting in anovulation in females and impaired spermatogenesis in males. Disruption of the LH signaling axis is also a recognized cause of Leydig cell hypoplasia and various forms of male pseudohermaphroditism.