抗人 Leukotriene A4 Hydrolase 抗体对
01AB00886
Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme with both epoxide hydrolase and aminopeptidase activities. It catalyzes the conversion of Leukotriene A4 (LTA4) to Leukotriene B4 (LTB4), a potent pro-inflammatory mediator, through its epoxide hydrolase function. Additionally, LTA4H exhibits aminopeptidase activity, cleaving N-terminal arginines from tripeptides and inactivating the neutrophil attractant Pro-Gly-Pro (PGP), thereby counteracting inflammation. The enzyme is also involved in the biosynthesis of resolvin E1 and 18S-resolvin E1, lipid mediators with anti-inflammatory and pro-resolving effects. Structurally, LTA4H is a cytosolic protein found in most mammalian cells and belongs to the peptidase M1 family. Phosphorylation at Ser-416 inhibits its hydrolase activity, providing a regulatory mechanism. Dysregulation of LTA4H is implicated in inflammatory diseases, cancer, and tuberculosis, with genetic polymorphisms influencing disease severity and response to therapy.
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技术参数
- 靶点基因名
- LTA4H
- 基因别名
- LTA4
- 蛋白别名
- leukotriene A4 hydrolase; Leukotriene A4 Hydrolase
- UniProt
- P09960
- 物种
- Human
产品详情
- 靶点名称
- Leukotriene A4 Hydrolase
- 蛋白名称
- leukotriene A4 hydrolase
- 蛋白别名
- Leukotriene A-4 hydrolase; LTA-4 hydrolase; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H
- 靶点基因名
- LTA4H
- 基因别名
- LTA4
- UniProt
- P09960
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme with both epoxide hydrolase and aminopeptidase activities. It catalyzes the conversion of Leukotriene A4 (LTA4) to Leukotriene B4 (LTB4), a potent pro-inflammatory mediator, through its epoxide hydrolase function. Additionally, LTA4H exhibits aminopeptidase activity, cleaving N-terminal arginines from tripeptides and inactivating the neutrophil attractant Pro-Gly-Pro (PGP), thereby counteracting inflammation. The enzyme is also involved in the biosynthesis of resolvin E1 and 18S-resolvin E1, lipid mediators with anti-inflammatory and pro-resolving effects. Structurally, LTA4H is a cytosolic protein found in most mammalian cells and belongs to the peptidase M1 family. Phosphorylation at Ser-416 inhibits its hydrolase activity, providing a regulatory mechanism. Dysregulation of LTA4H is implicated in inflammatory diseases, cancer, and tuberculosis, with genetic polymorphisms influencing disease severity and response to therapy.