抗人 LEFTY2 抗体对
01AB01510
Left-right determination factor 2 (LEFTY2), also known as TGFB4 or Endometrial Bleeding-Associated Factor, is a secreted protein belonging to the TGF-beta cytokine family, with a molecular weight of approximately 39.1 kDa. LEFTY2 is produced as a recombinant protein in mammalian systems, typically spanning residues Phe78-Pro366, and is characterized by high purity and low endotoxin levels in research applications. Functionally, LEFTY2 plays a crucial role in establishing left-right asymmetry during embryonic development, particularly influencing the patterning of organ systems such as the heart and lungs across vertebrates. Mutations or dysregulation of LEFTY2 are associated with congenital left-right axis malformations, especially affecting the heart and lungs, and abnormal expression has also been linked to certain infertility cases and endometrial bleeding disorders.
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技术参数
- 靶点基因名
- LEFTY2
- 基因别名
- EBAF; LEFTA; LEFTYA; TGFB4
- 蛋白别名
- left-right determination factor 2; LEFTY2
- UniProt
- O00292
- 物种
- Human
产品详情
- 靶点名称
- LEFTY2
- 蛋白名称
- left-right determination factor 2
- 蛋白别名
- Left-right determination factor 2; Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4
- 靶点基因名
- LEFTY2
- 基因别名
- EBAF; LEFTA; LEFTYA; TGFB4
- UniProt
- O00292
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Left-right determination factor 2 (LEFTY2), also known as TGFB4 or Endometrial Bleeding-Associated Factor, is a secreted protein belonging to the TGF-beta cytokine family, with a molecular weight of approximately 39.1 kDa. LEFTY2 is produced as a recombinant protein in mammalian systems, typically spanning residues Phe78-Pro366, and is characterized by high purity and low endotoxin levels in research applications. Functionally, LEFTY2 plays a crucial role in establishing left-right asymmetry during embryonic development, particularly influencing the patterning of organ systems such as the heart and lungs across vertebrates. Mutations or dysregulation of LEFTY2 are associated with congenital left-right axis malformations, especially affecting the heart and lungs, and abnormal expression has also been linked to certain infertility cases and endometrial bleeding disorders.