抗人 LAT 抗体对
01AB00685
Linker for Activation of T Cells (LAT) is a transmembrane adaptor protein crucial for transducing intracellular signals from the TCR/CD3 complex in T cells. LAT has a short extracellular N-terminal fragment, a hydrophobic transmembrane segment, and a long cytoplasmic tail containing nine conserved tyrosine residues. Upon TCR engagement, LAT becomes rapidly tyrosine-phosphorylated, creating binding sites for various signaling proteins such as PLC-γ1, Grb2, Gads, and SLP-76, which are essential for downstream signaling cascades. LAT is localized to the glycolipid-enriched membrane (GEM) subdomains of the plasma membrane by palmitoylation. Defects in LAT function lead to impaired T cell activation, including reduced intracellular calcium, Ras activation, and IL-2 production. LAT is also involved in regulating T cell memory differentiation and is necessary for memory CD8 T cells to proliferate and produce cytokines upon antigen re-exposure.
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技术参数
- 靶点基因名
- LAT
- 蛋白别名
- linker for activation of T cells; LAT
- UniProt
- O43561
- 物种
- Human
产品详情
- 靶点名称
- LAT
- 蛋白名称
- linker for activation of T cells
- 蛋白别名
- Linker for activation of T-cells family member 1; 36 kDa phosphotyrosine adapter protein; pp36; p36-38
- 靶点基因名
- LAT
- UniProt
- O43561
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Linker for Activation of T Cells (LAT) is a transmembrane adaptor protein crucial for transducing intracellular signals from the TCR/CD3 complex in T cells. LAT has a short extracellular N-terminal fragment, a hydrophobic transmembrane segment, and a long cytoplasmic tail containing nine conserved tyrosine residues. Upon TCR engagement, LAT becomes rapidly tyrosine-phosphorylated, creating binding sites for various signaling proteins such as PLC-γ1, Grb2, Gads, and SLP-76, which are essential for downstream signaling cascades. LAT is localized to the glycolipid-enriched membrane (GEM) subdomains of the plasma membrane by palmitoylation. Defects in LAT function lead to impaired T cell activation, including reduced intracellular calcium, Ras activation, and IL-2 production. LAT is also involved in regulating T cell memory differentiation and is necessary for memory CD8 T cells to proliferate and produce cytokines upon antigen re-exposure.