人 LAMA4 抗体对
01AB03310
Laminin subunit alpha-4 (LAMA4) is a critical component of the laminin family of extracellular matrix proteins, which are essential for maintaining the structural integrity of basement membranes. LAMA4 plays significant roles in cell adhesion, migration, differentiation, and signaling, contributing to various biological processes such as tissue development and repair. LAMA4 contains a C-terminal G domain that distinguishes it from the beta and gamma laminin chains. Dysregulation of LAMA4 has been implicated in several diseases, particularly in cardiovascular disorders, where mutations in the LAMA4 gene can lead to dilated cardiomyopathy. The high levels of LAMA4 are often found in aggressive tumors, facilitating tumor cell invasion and metastasis. Furthermore, LAMA4 has been linked to congenital muscular dystrophies, emphasizing its importance in muscle integrity and function.
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技术参数
- 靶点基因名
- LAMA4
- 蛋白别名
- laminin subunit alpha 4; LAMA4
- UniProt
- Q16363
- 物种
- Human
产品详情
- 靶点名称
- LAMA4
- 蛋白名称
- laminin subunit alpha 4
- 蛋白别名
- Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha
- 靶点基因名
- LAMA4
- UniProt
- Q16363
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Laminin subunit alpha-4 (LAMA4) is a critical component of the laminin family of extracellular matrix proteins, which are essential for maintaining the structural integrity of basement membranes. LAMA4 plays significant roles in cell adhesion, migration, differentiation, and signaling, contributing to various biological processes such as tissue development and repair. LAMA4 contains a C-terminal G domain that distinguishes it from the beta and gamma laminin chains. Dysregulation of LAMA4 has been implicated in several diseases, particularly in cardiovascular disorders, where mutations in the LAMA4 gene can lead to dilated cardiomyopathy. The high levels of LAMA4 are often found in aggressive tumors, facilitating tumor cell invasion and metastasis. Furthermore, LAMA4 has been linked to congenital muscular dystrophies, emphasizing its importance in muscle integrity and function.