抗人 LAIR2 抗体对
01AB01504
Leukocyte associated immunoglobulin like receptor 2 (LAIR2) is a soluble protein belonging to the immunoglobulin superfamily, encoded by the LAIR2 gene located in the leukocyte receptor cluster on chromosome 19q13.4. Structurally, LAIR2 consists of a single Ig-like domain closely resembling that of LAIR1, but unlike LAIR1, it lacks transmembrane and intracellular signaling domains, making it a circulating, extracellular protein. Functionally, LAIR2 acts as a decoy receptor by binding to collagen in the extracellular matrix, thereby preventing LAIR1 from interacting with its ligands and blocking the inhibitory signals that would otherwise dampen immune cell activity. This mechanism is crucial for modulating immune responses, particularly in collagen-rich environments, and helps maintain a balance between immune activation and inhibition. Clinically, LAIR2’s regulatory role is significant in contexts such as cancer, autoimmunity, and infection, where altered immune regulation can contribute to disease progression or immune evasion by tumors.
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技术参数
- 靶点基因名
- LAIR2
- 基因别名
- CD306
- 蛋白别名
- leukocyte associated immunoglobulin like receptor 2; LAIR2
- UniProt
- Q6ISS4
- 物种
- Human
产品详情
- 靶点名称
- LAIR2
- 蛋白名称
- leukocyte associated immunoglobulin like receptor 2
- 蛋白别名
- Leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; CD antigen CD306
- 靶点基因名
- LAIR2
- 基因别名
- CD306
- UniProt
- Q6ISS4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Leukocyte associated immunoglobulin like receptor 2 (LAIR2) is a soluble protein belonging to the immunoglobulin superfamily, encoded by the LAIR2 gene located in the leukocyte receptor cluster on chromosome 19q13.4. Structurally, LAIR2 consists of a single Ig-like domain closely resembling that of LAIR1, but unlike LAIR1, it lacks transmembrane and intracellular signaling domains, making it a circulating, extracellular protein. Functionally, LAIR2 acts as a decoy receptor by binding to collagen in the extracellular matrix, thereby preventing LAIR1 from interacting with its ligands and blocking the inhibitory signals that would otherwise dampen immune cell activity. This mechanism is crucial for modulating immune responses, particularly in collagen-rich environments, and helps maintain a balance between immune activation and inhibition. Clinically, LAIR2’s regulatory role is significant in contexts such as cancer, autoimmunity, and infection, where altered immune regulation can contribute to disease progression or immune evasion by tumors.