人 L1CAM 抗体对
01AB02584
L1 cell adhesion molecule (L1CAM) is a critical transmembrane glycoprotein involved in neuronal development, promoting cell adhesion, migration, and neurite outgrowth. It consists of six immunoglobulin-like domains and five fibronectin type III domains, facilitating both homophilic and heterophilic interactions essential for neuronal connectivity and myelination processes. L1CAM's dysregulation is implicated in various cancers, including ovarian and gastric cancers, where its overexpression correlates with enhanced cell proliferation, invasion, and metastasis, marking it as a potential biomarker for aggressive tumors. In contrast, mutations in the L1CAM gene lead to L1 syndrome (CRASH), characterized by neurological disorders such as corpus callosum hypoplasia and spastic paraplegia, predominantly affecting males.
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技术参数
- 靶点基因名
- L1CAM
- 基因别名
- CAML1; MIC5
- 蛋白别名
- L1 cell adhesion molecule; L1CAM
- UniProt
- P32004
- 物种
- Human
产品详情
- 靶点名称
- L1CAM
- 蛋白名称
- L1 cell adhesion molecule
- 蛋白别名
- Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD antigen CD171
- 靶点基因名
- L1CAM
- 基因别名
- CAML1; MIC5
- UniProt
- P32004
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
L1 cell adhesion molecule (L1CAM) is a critical transmembrane glycoprotein involved in neuronal development, promoting cell adhesion, migration, and neurite outgrowth. It consists of six immunoglobulin-like domains and five fibronectin type III domains, facilitating both homophilic and heterophilic interactions essential for neuronal connectivity and myelination processes. L1CAM's dysregulation is implicated in various cancers, including ovarian and gastric cancers, where its overexpression correlates with enhanced cell proliferation, invasion, and metastasis, marking it as a potential biomarker for aggressive tumors. In contrast, mutations in the L1CAM gene lead to L1 syndrome (CRASH), characterized by neurological disorders such as corpus callosum hypoplasia and spastic paraplegia, predominantly affecting males.