人 KYNU 抗体对
01AB01702
KYNU is an enzyme that plays a key role in the kynurenine pathway, which is the primary metabolic pathway for the essential amino acid tryptophan. KYNU catalyzes the conversion of kynurenine and 3-hydroxy-L-kynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively. This pathway generates various neuroactive metabolites that have been implicated in a range of neurological and inflammatory diseases. Dysregulation of the kynurenine pathway and altered KYNU activity have been associated with several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. KYNU expression is also increased in inflammatory bowel diseases, where it may play a role in the development and progression of chronic inflammation. Additionally, genetic variations in the KYNU gene have been linked to cardiovascular diseases and certain types of cancer.
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|---|---|
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技术参数
- 靶点基因名
- KYNU
- 蛋白别名
- kynureninase; KYNU
- UniProt
- Q16719
- 物种
- Human
产品详情
- 靶点名称
- KYNU
- 蛋白名称
- kynureninase
- 蛋白别名
- Kynureninase; L-kynurenine hydrolase
- 靶点基因名
- KYNU
- UniProt
- Q16719
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
KYNU is an enzyme that plays a key role in the kynurenine pathway, which is the primary metabolic pathway for the essential amino acid tryptophan. KYNU catalyzes the conversion of kynurenine and 3-hydroxy-L-kynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively. This pathway generates various neuroactive metabolites that have been implicated in a range of neurological and inflammatory diseases. Dysregulation of the kynurenine pathway and altered KYNU activity have been associated with several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. KYNU expression is also increased in inflammatory bowel diseases, where it may play a role in the development and progression of chronic inflammation. Additionally, genetic variations in the KYNU gene have been linked to cardiovascular diseases and certain types of cancer.