人 KYAT1 抗体对
01AB01750
Kynurenine aminotransferase 1 (KYAT1) is a cytosolic, pyridoxal 5'-phosphate (PLP)-dependent enzyme that plays a central role in the tryptophan catabolic pathway. It catalyzes the irreversible transamination of L-kynurenine to produce kynurenic acid, a neuroactive metabolite that modulates glutamatergic neurotransmission. Additionally, KYAT1 exhibits beta-lyase activity toward sulfur- and selenium-containing cysteine conjugates, a process that can generate reactive intermediates linked to nephrotoxicity. Structurally, the enzyme functions as a dimer with a well-defined active site containing key catalytic residues such as Lys247 and Glu27. Clinically, KYAT1 is associated with hydroxykynureninuria and schizophrenia, as dysregulation of kynurenic acid homeostasis is implicated in various neuropsychiatric and neurodegenerative conditions.
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技术参数
- 靶点基因名
- KYAT1
- 基因别名
- CCBL1
- 蛋白别名
- kynurenine aminotransferase 1; KYAT1
- UniProt
- Q16773
- 物种
- Human
产品详情
- 靶点名称
- KYAT1
- 蛋白名称
- kynurenine aminotransferase 1
- 蛋白别名
- Kynurenine--oxoglutarate transaminase 1; Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I
- 靶点基因名
- KYAT1
- 基因别名
- CCBL1
- UniProt
- Q16773
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Kynurenine aminotransferase 1 (KYAT1) is a cytosolic, pyridoxal 5'-phosphate (PLP)-dependent enzyme that plays a central role in the tryptophan catabolic pathway. It catalyzes the irreversible transamination of L-kynurenine to produce kynurenic acid, a neuroactive metabolite that modulates glutamatergic neurotransmission. Additionally, KYAT1 exhibits beta-lyase activity toward sulfur- and selenium-containing cysteine conjugates, a process that can generate reactive intermediates linked to nephrotoxicity. Structurally, the enzyme functions as a dimer with a well-defined active site containing key catalytic residues such as Lys247 and Glu27. Clinically, KYAT1 is associated with hydroxykynureninuria and schizophrenia, as dysregulation of kynurenic acid homeostasis is implicated in various neuropsychiatric and neurodegenerative conditions.