抗人 KSR2 抗体对
01AB01978
Kinase suppressor of ras 2 (KSR2) is a large cytosolic scaffold protein that organizes the RAF–MEK–ERK MAPK signaling cascade. Although it possesses low intrinsic kinase activity, it acts as a location-regulated allosteric activator by binding BRAF and MEK1 to facilitate their phosphorylation. Predominantly expressed in the brain and metabolically active tissues, KSR2 also interacts with AMP-activated protein kinase (AMPK) to link Ras/MAPK signaling with energy-sensing pathways, thereby regulating feeding behavior, substrate utilization, and adaptive thermogenesis. Loss-of-function variants in KSR2 are strongly associated with severe early-onset obesity, hyperphagia, reduced basal metabolic rate, and marked insulin resistance, establishing it as a critical regulator of systemic energy homeostasis.
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技术参数
- 靶点基因名
- KSR2
- 蛋白别名
- kinase suppressor of ras 2; KSR2
- UniProt
- Q6VAB6
- 物种
- Human
产品详情
- 靶点名称
- KSR2
- 蛋白名称
- kinase suppressor of ras 2
- 蛋白别名
- Kinase suppressor of Ras 2; hKSR2
- 靶点基因名
- KSR2
- UniProt
- Q6VAB6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Kinase suppressor of ras 2 (KSR2) is a large cytosolic scaffold protein that organizes the RAF–MEK–ERK MAPK signaling cascade. Although it possesses low intrinsic kinase activity, it acts as a location-regulated allosteric activator by binding BRAF and MEK1 to facilitate their phosphorylation. Predominantly expressed in the brain and metabolically active tissues, KSR2 also interacts with AMP-activated protein kinase (AMPK) to link Ras/MAPK signaling with energy-sensing pathways, thereby regulating feeding behavior, substrate utilization, and adaptive thermogenesis. Loss-of-function variants in KSR2 are strongly associated with severe early-onset obesity, hyperphagia, reduced basal metabolic rate, and marked insulin resistance, establishing it as a critical regulator of systemic energy homeostasis.