人 KIR3DL1 抗体对
01AB03290
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) is a member of the KIR family of receptors, which are expressed on natural killer (NK) cells and some T cells. This receptor is characterized by its ability to recognize specific human leukocyte antigen (HLA) class I molecules, particularly those expressing the Bw4 epitope of HLA-A and HLA-B. KIR3DL1 plays a critical role in regulating NK cell activity, providing inhibitory signals that prevent the destruction of healthy cells while allowing for the targeting of infected or malignant cells. Dysregulation or altered expression of KIR3DL1 has been associated with several conditions, including viral infections such as HIV, where certain alleles may confer protection or increased susceptibility. Additionally, its interaction with HLA molecules is implicated in the outcomes of organ transplantation and autoimmune diseases.
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技术参数
- 靶点基因名
- KIR3DL1
- 基因别名
- CD158E; NKAT3; NKB1
- 蛋白别名
- killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL1
- UniProt
- P43629
- 物种
- Human
产品详情
- 靶点名称
- KIR3DL1
- 蛋白名称
- killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
- 蛋白别名
- Killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD antigen CD158e
- 靶点基因名
- KIR3DL1
- 基因别名
- CD158E; NKAT3; NKB1
- UniProt
- P43629
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) is a member of the KIR family of receptors, which are expressed on natural killer (NK) cells and some T cells. This receptor is characterized by its ability to recognize specific human leukocyte antigen (HLA) class I molecules, particularly those expressing the Bw4 epitope of HLA-A and HLA-B. KIR3DL1 plays a critical role in regulating NK cell activity, providing inhibitory signals that prevent the destruction of healthy cells while allowing for the targeting of infected or malignant cells. Dysregulation or altered expression of KIR3DL1 has been associated with several conditions, including viral infections such as HIV, where certain alleles may confer protection or increased susceptibility. Additionally, its interaction with HLA molecules is implicated in the outcomes of organ transplantation and autoimmune diseases.