抗人 KIF1C 抗体对
01AB02722
Kinesin family member 1C (KIF1C) is a plus-end-directed microtubule motor belonging to the kinesin-3 family, primarily involved in the transport of Golgi- and endosome-derived vesicles. It functions as a stable homodimer featuring an N-terminal ATP-dependent motor domain and a forkhead-associated (FHA) domain that facilitates interactions with cargo and regulatory proteins. KIF1C is essential for maintaining Golgi ribbon organization and participates in bidirectional transport through functional coupling with dynein-dynactin adapters such as HOOK3 and BICDR1. It is highly expressed in the brain and immune cells, where it supports critical intracellular trafficking pathways. Clinically, pathogenic biallelic variants in KIF1C are the cause of a spectrum of neurodegenerative disorders, including autosomal recessive hereditary spastic paraplegia and spinocerebellar ataxia type 58, characterized by progressive spastic paraparesis and cerebellar ataxia.
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技术参数
- 靶点基因名
- KIF1C
- 基因别名
- KIAA0706
- 蛋白别名
- kinesin family member 1C; KIF1C
- UniProt
- O43896
- 物种
- Human
产品详情
- 靶点名称
- KIF1C
- 蛋白名称
- kinesin family member 1C
- 蛋白别名
- Kinesin-like protein KIF1C
- 靶点基因名
- KIF1C
- 基因别名
- KIAA0706
- UniProt
- O43896
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Kinesin family member 1C (KIF1C) is a plus-end-directed microtubule motor belonging to the kinesin-3 family, primarily involved in the transport of Golgi- and endosome-derived vesicles. It functions as a stable homodimer featuring an N-terminal ATP-dependent motor domain and a forkhead-associated (FHA) domain that facilitates interactions with cargo and regulatory proteins. KIF1C is essential for maintaining Golgi ribbon organization and participates in bidirectional transport through functional coupling with dynein-dynactin adapters such as HOOK3 and BICDR1. It is highly expressed in the brain and immune cells, where it supports critical intracellular trafficking pathways. Clinically, pathogenic biallelic variants in KIF1C are the cause of a spectrum of neurodegenerative disorders, including autosomal recessive hereditary spastic paraplegia and spinocerebellar ataxia type 58, characterized by progressive spastic paraparesis and cerebellar ataxia.