抗人 KIF16B 抗体对
01AB01189
Kinesin family member 16B (KIF16B) is a plus end-directed, microtubule-dependent motor protein belonging to the kinesin-3 family, widely expressed in various tissues such as brain, heart, liver, kidney, placenta, skeletal muscle, and white blood cells. Structurally, KIF16B features an N-terminal motor domain, multiple coiled-coil regions for dimerization, and a C-terminal cargo-binding domain with a unique PX domain that binds the membrane lipid PI(3)P, enabling it to directly interact with endosomal membranes. It exhibits a “stalk inhibition” mechanism that regulates its microtubule association and is notable for its superprocessive motility, with an average run length of approximately 10 μm, making it highly effective for long-range intracellular transport. Functionally, KIF16B is crucial for endosome transport, receptor recycling, and degradation, and it drives rapid recycling of MT1-MMP in macrophages, influencing processes such as cancer cell co-invasion. Disease associations include links to prostate cancer, congenital fibrosis of the extraocular muscles, nonsmall cell lung cancer survival, and autosomal-recessive intellectual disability syndrome.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- KIF16B
- 基因别名
- C20orf23; KIAA1590; SNX23
- 蛋白别名
- kinesin family member 16B; KIF16B
- UniProt
- Q96L93
- 物种
- Human
产品详情
- 靶点名称
- KIF16B
- 蛋白名称
- kinesin family member 16B
- 蛋白别名
- Kinesin-like protein KIF16B; Sorting nexin-23
- 靶点基因名
- KIF16B
- 基因别名
- C20orf23; KIAA1590; SNX23
- UniProt
- Q96L93
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Kinesin family member 16B (KIF16B) is a plus end-directed, microtubule-dependent motor protein belonging to the kinesin-3 family, widely expressed in various tissues such as brain, heart, liver, kidney, placenta, skeletal muscle, and white blood cells. Structurally, KIF16B features an N-terminal motor domain, multiple coiled-coil regions for dimerization, and a C-terminal cargo-binding domain with a unique PX domain that binds the membrane lipid PI(3)P, enabling it to directly interact with endosomal membranes. It exhibits a “stalk inhibition” mechanism that regulates its microtubule association and is notable for its superprocessive motility, with an average run length of approximately 10 μm, making it highly effective for long-range intracellular transport. Functionally, KIF16B is crucial for endosome transport, receptor recycling, and degradation, and it drives rapid recycling of MT1-MMP in macrophages, influencing processes such as cancer cell co-invasion. Disease associations include links to prostate cancer, congenital fibrosis of the extraocular muscles, nonsmall cell lung cancer survival, and autosomal-recessive intellectual disability syndrome.