人 Ki67 抗体对
01AB02218
MKI67, also known as Ki-67, is a nuclear protein that plays a crucial role in cell proliferation and ribosomal RNA transcription. Its expression levels correlate with the growth fraction of a cell population, making it a valuable biomarker for various cancers like breast, prostate, and brain carcinomas. Higher MKI67 expression is associated with increased tumor aggressiveness, metastasis, and poor prognosis in many cancers. Additionally, MKI67 facilitates the proliferation and migration of pulmonary arterial smooth muscle cells, suggesting its potential involvement in pulmonary hypertension pathogenesis. MKI67 interacts with key cell cycle regulators like RB, p53, and DREAM/MuvB complexes, regulating its expression during cell cycle progression, DNA damage response, and cellular stress. Therefore, MKI67 serves as both a diagnostic and prognostic biomarker and a potential therapeutic target in various malignancies and proliferative disorders.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- MKI67
- 蛋白别名
- marker of proliferation Ki-67; Ki67
- UniProt
- P46013
- 物种
- Human
产品详情
- 靶点名称
- Ki67
- 蛋白名称
- marker of proliferation Ki-67
- 蛋白别名
- Proliferation marker protein Ki-67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen Ki67
- 靶点基因名
- MKI67
- UniProt
- P46013
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MKI67, also known as Ki-67, is a nuclear protein that plays a crucial role in cell proliferation and ribosomal RNA transcription. Its expression levels correlate with the growth fraction of a cell population, making it a valuable biomarker for various cancers like breast, prostate, and brain carcinomas. Higher MKI67 expression is associated with increased tumor aggressiveness, metastasis, and poor prognosis in many cancers. Additionally, MKI67 facilitates the proliferation and migration of pulmonary arterial smooth muscle cells, suggesting its potential involvement in pulmonary hypertension pathogenesis. MKI67 interacts with key cell cycle regulators like RB, p53, and DREAM/MuvB complexes, regulating its expression during cell cycle progression, DNA damage response, and cellular stress. Therefore, MKI67 serves as both a diagnostic and prognostic biomarker and a potential therapeutic target in various malignancies and proliferative disorders.